Results 51 to 60 of about 3,418,038 (298)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Challenges in evaluating surgical innovation [PDF]

, 2009
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Ergina, Patrick L, Seiler, Christoph M, Boutron, Isabelle, Blazeby, Jane M, Cook, Jonathan Alistair, Clavein, Pierre-Alain, Reeves, Barnaby C   +6 more
core   +2 more sources

Review of surgical ventricular restoration: A procedure to treat cardiac failure [PDF]

Indian Journal of Surgery, 2010
Severe heart failure refractory to medical treatment necessitates the use of other modalities of treatment. Surgical ventricular restoration (SVR) surgery can provide relief until donour hearts are available or when transplantation is contraindicated. In this review we look at the physiological basis for improvement in cardiac function and cardiac and ...
Anupam A, Sule, Ajey A, Sule, Downey H, Fred, Sanjeev S, Thakur   +3 more
openaire   +2 more sources

Kawasaki disease: Surgical treatment

, 2022
Kawasaki disease (KD) is a systemic vasculitis of small and medium arteries, preferably affecting coronary arteries. It is one of the most frequent causes of acquired heart disease in children.
Mulinari, Leonardo, Navarro, Fabio B
core   +1 more source

Operative management after transcatheter aortic valve replacement [PDF]

, 2023
With broadening applications of transcatheter aortic valve replacement (TAVR) and increasing use in intermediate- and low-risk patients, the incidence of surgical re-interventions after TAVR is growing. Transcatheter heart valves suffer from similar long-
Crestanello, Juan A; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, United States, Arghami, Arman; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, United States, Marin-Cuartas, Mateo; University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany, Noack, Thilo; University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany, Borger, Michael A; University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany, Mazur, Piotr; University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, United States, Michael A Borger, Mateo Marin-Cuartas, Thilo Noack, Juan A Crestanello, Piotr Mazur, Arman Arghami   +11 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Cardiovascular Surgery Patients: Intensive Care Experiences and Associated Factors

Asian Nursing Research, 2015
Purpose: The purpose of this study was to determine the intensive care unit (ICU) experiences of cardiovascular surgery (CS) patients and to define the associations between their ICU experiences and related factors.
Özlem Aslan, RN, PhD, Betül Tosun, RN, PhD   +1 more
doaj   +1 more source

Cardiac papillary fibroelastomas: A 10-year single-center surgical experience and long-term echocardiographic follow-up study

Biomedical Papers, 2020
Aims: Limited contemporary data are available on the clinical and echocardiographic outcomes after surgery for cardiac papillary fibroelastoma (CPF). The aim of this study was to review the clinical manifestations, pathological characteristics, surgical ...
Martin Kolek, Jana Dvorackova, Oldrich Motyka, Radim Brat   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Myocardial necrosis biomarkers after different cardiac surgical operations

, 2007
A high postoperative peak of cardiac Troponin I is associated to an increased risk of morbidity and mortality after cardiac operations. The aim of this study was to investigate the release of cardiac Troponin I in different cardiac surgical ...
M. G. Calabrò, G. Landoni, F. Pappalardo, F. Boroli, G. Crescenzi, G. Aletti, O. Sottocorna, A. Zangrillo   +7 more
core   +2 more sources