Results 121 to 130 of about 4,418,542 (362)

MMP-2 and sTNF-R1 variability in patients with essential hypertension: 1-year follow-up study [PDF]

open access: yes, 2012
The aim of this study is to analyze MMP-2 and sTNF-R1 variability, potent predictors of cardiovascular events, in stable hypertensive patients during a 12-month followup.
Calabuig, Jose R.   +10 more
core   +3 more sources

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan   +7 more
wiley   +1 more source

Caseous mitral annulus calcification: A forgotten benign condition mimicking cardiac mass, a case report

open access: yesClinical Case Reports
Key Clinical Message Caseous mitral annulus calcification is a rare benign condition that can be misdiagnosed on echocardiography especially when it presents as a mass. This report highlights the contribution of cardiac MRI and computed tomography to the
Henda Nèji   +6 more
doaj   +1 more source

Elastic free energy drives the shape of prevascular solid tumors [PDF]

open access: yes, 2014
It is well established that the mechanical environment influences cell functions in health and disease. Here, we address how the mechanical environment influences tumor growth, in particular, the shape of solid tumors. In an in vitro tumor model, which isolates mechanical interactions between tumor cells and a hydrogel, we find that tumors grow as ...
arxiv   +1 more source

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]

open access: yes, 2020
Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila   +3 more
core  

EMT/MET at the crossroad of stemness, regeneration and oncogenesis. The Ying-Yang equilibrium recapitulated in cell spheroids [PDF]

open access: yes, 2017
The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression.
Angelini, Francesco   +7 more
core   +2 more sources

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

open access: yesArthritis Care &Research, Volume 77, Issue 5, Page 584-593, May 2025.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner   +12 more
wiley   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

open access: yesAdvanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang   +6 more
wiley   +1 more source

Difficulties in Differentiating Cardiac Lymphoma and Metastasis Based on Radiologic Features: Two Case Reports

open access: yes대한영상의학회지, 2021
Cardiac tumors are rare diseases with various imaging findings. However, differentiating cardiac tumors based on imaging findings is challenging because of similarities in imaging features.
Hyun Jae Lim   +4 more
doaj   +1 more source

Relating the spectrum of cardiac signals to the spatiotemporal dynamics of cardiac sources [PDF]

open access: yesarXiv, 2013
An increasing number of studies use the spectrum of cardiac signals for analyzing the spatiotemporal dynamics of complex cardiac arrhythmias. However, the relationship between the spectrum of cardiac signals and the spatiotemporal dynamics of the underlying cardiac sources remains to date unclear.
arxiv  

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