Results 91 to 100 of about 185,757 (265)

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Characteristics of myocardial work during exercise stress echocardiography in healthy adults

Frontiers in Cardiovascular Medicine
BackgroundNon-invasive myocardial work (MW) is a more precise parameter for evaluating left ventricular (LV) systolic function. However, studies examining sex-based differences in MW during exercise stress echocardiography (SE) in healthy individuals are
Liwei Huang, Liwei Huang, Luwei Ye, Luwei Ye, Hongmei Zhang, Hongmei Zhang, Qingfeng Zhang, Qingfeng Zhang, Geqi Ding, Geqi Ding, Chunmei Li, Chunmei Li, Yan Deng, Yan Deng, Lixue Yin, Lixue Yin, Yi Wang, Yi Wang   +17 more
doaj   +1 more source

Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems

Advanced Science, EarlyView.
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu, Siyu Liang, Jingyi Niu, Jie Chen, Shuo Zhang, Hongjian Zhang, Dongsheng Jia, Wei Huang   +7 more
wiley   +1 more source

Correction: Lactate metabolism in human health and disease

Signal Transduction and Targeted Therapy, 2022
Xiaolu Li, Yanyan Yang, Bei Zhang, Xiaotong Lin, Xiuxiu Fu, Yi An, Yulin Zou, Jian-Xun Wang, Zhibin Wang, Tao Yu   +9 more
doaj   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Rapid bedside multimodal ultrasound screening for acute type A aortic dissection: a perspective

Frontiers in Cardiovascular Medicine
Acute type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency where delays in diagnosis worsen outcomes. While computed tomography angiography remains the diagnostic gold standard, its requirement for patient transport, contrast ...
Hua Xu, Jin-Yan Yang
doaj   +1 more source

Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

Advanced Science, EarlyView.
The SPG‐MpECis electrochemical POCT platform developed in this study enables direct detection of biomarkers in complex biological samples such as serum and fingerstick blood, demonstrating high concordance with results from clinical reference methods and holding broad potential for at‐home testing applications.
Menghan Li, Kai Su, Ruiwei Hu, Ke Gao, Yuanjie Liu, Lu Zhang, Ningke Fan, Yirong Chen, Wei Cheng, Shijia Ding, Haiping Wu   +10 more
wiley   +1 more source

Left atrial energy loss as a novel predictor of mortality and cardiovascular events in chronic kidney disease patients with preserved ejection fraction

BMC Cardiovascular Disorders
Background Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular adverse events and abnormal intracardiac blood flow, which are commonly underestimated when evaluated by traditional echocardiographic parameters. Energy loss (
Xiaoxue Chen, Daoqin Li, Wei Wang, Zhengqin Qi, Kun Xue, Lijuan Sun, Chengyu Yang, Xuejie Shen, Degang Song   +8 more
doaj   +1 more source