Results 241 to 250 of about 110,986 (307)

On the Book of Devotions, Deposited by Cardinal Howard in the Library of the Dominican Convent at Bornheim in 1659

Joseph Hunter
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Clinical outcomes and complications of robotic-assisted spine surgery: using the ExcelsiusGPS system: a single-surgeon case series. [PDF]

J Robot Surg
Singh E, Cardinal T, Stillman K, Jackson S, Cable C, Di L, Tigchelaar S, Khalafallah A, Urakov T.   +8 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Neuroanatomical Analysis of the Carpus and the Base of the Thumb: Advancing Denervation-Based Interventions. [PDF]

Cureus
Watzig BF, Champagne L, Sekar M, Hui C, Cardinal J, Nulty S, Huynh T, Eisenberg M, Hustedt JW.   +8 more
europepmc   +1 more source

Evidence for the evolution of male and female cardinals' plumage colouration being affected by both natural and sexual selection. [PDF]

BMC Ecol Evol
Porzio NS, Mota PG.
europepmc   +1 more source

Postoperative Mechanical Bowel Obstruction Secondary to Jackson-Pratt (JP) Drain Placement in a Patient With Perforated Appendicitis. [PDF]

Cureus
Ramesh Babu YS, Patel KJ, Obregon J, Kahane O, Kahane G, Morejon O.   +5 more
europepmc   +1 more source

Eyes on hold: motion task difficulty jointly delays microsaccade and pupil responses. [PDF]

Sci Rep
Ezzo R, Song B, Rokers B, Carrasco M.
europepmc   +1 more source

Coverage Checker: A Web-Based Tool to Navigate Diabetes Coverage and Prior Authorization. [PDF]

Ann Fam Med
Kim N, Cardinal S, Gabison J, Oshman L, Rau J, Reiss J, Young L, Diez HL.   +7 more
europepmc   +1 more source