Results 111 to 120 of about 56,992 (233)
Movement Disorders, EarlyView.Abstract Background Many patients with Parkinson's disease (PD) have motor impairments despite dopaminergic therapy. Low‐intensity transcranial ultrasound stimulation (TUS) is a non‐invasive neuromodulation method with high spatial precision. The effects of motor cortex (M1) and internal globus pallidus (GPi) TUS on PD motor signs and cortical ...
Yi‐Ying Lin +8 more
wiley +1 more source
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
Bipolar Disorder as a Long‐Term Risk Factor for Parkinson's Disease: A Nationwide Case–Control Study
Movement Disorders, EarlyView.Abstract Background Previous studies suggest an association between bipolar disorder (BD) and an increased risk of Parkinson's disease (PD), but the long‐term temporal relationship remains unclear. Particularly, it is unclear whether the risk of PD is influenced by the duration since BD diagnosis.
Elina Jaakkola +5 more
wiley +1 more source
Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Focused ultrasound is rapidly emerging as a novel technology for the development of symptomatic therapies and supporting disease‐modifying treatments for Parkinson's disease (PD). At the forefront of this development is thermoablation using high‐intensity focused ultrasound, an incisionless treatment that has been extensively tested in ...
Rikke Hahn Kofoed +7 more
wiley +1 more source
Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients
Movement Disorders, EarlyView.Abstract Background Parkinsonism may be observed in multiple neurodegenerative diseases, including GRN‐associated frontotemporal dementia (FTD‐GRN), complicating the differential diagnosis of Parkinson's disease (PD). Objectives To investigate the presence of GRN variants in a large group of PD patients.
Christian A. Ganoza +31 more
wiley +1 more source
Finding Maximum Weight 2‐Packing Sets on Arbitrary Graphs
Networks, EarlyView.ABSTRACT A 2‐packing set for an undirected, weighted graph G=(V,E,w)$$ G=\left(V,\kern0.3em E,\kern0.3em w\right) $$ is a subset 𝒮⊆V such that any two vertices v1,v2∈𝒮 are not adjacent and have no common neighbors. The Maximum Weight 2‐Packing Set problem that asks for a 2‐packing set of maximum weight is NP$$ \mathbf{NP} $$‐hard. Next to 13 novel data
Jannick Borowitz +2 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Trees in cities provide a great number of benefits to people and nature, but they are challenged by harsh conditions. Trees rely on helpful fungi in their roots to get essential nutrients from the soil, but we do not know which of these fungi are resistant to city landscapes.
Casper T. Verbeek +2 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Drought and high temperatures are expected to increase in Europe, in particular in Mediterranean regions, where black truffle (Tuber melanosporum Vittad.) is mainly harvested. This fungus, living in symbiotic ectomycorrhizal association with trees, is important in forest ecosystems and agricultural diversification.
Lora Gigleux +8 more
wiley +1 more source
End‐to‐End Portfolio Optimization with Hybrid Quantum Annealing
Advanced Quantum Technologies, EarlyView.This works presents a hybrid quantum‐classical framework for portfolio optimization that combines quantum assisted asset selection and rebalancing with classical weight allocation. The approach processes real market data, embeds it into Quadratic Unconstrained Binary Optimization formulations, and evaluates performance within a unified workflow ...
Sai Nandan Morapakula +5 more
wiley +1 more source
Viscoelastic characterization of the human osteosarcoma cancer cell line MG-63 using a fractional-order zener model through automated algorithm design and configuration. [PDF]
Sci RepDuque-Gimenez GC +7 more
europepmc +1 more source