Results 121 to 130 of about 57,097 (242)

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Cardiogenic Shock [PDF]

, 1968
80% of people developing shock after myocardial infarction die. This essay is concerned to ask why they die and what can be done about it.Accordingly it consists of two parts: the one concerned with the definition and some relevant aspects of the ...
Leitch, Andrew Gordon
core  

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Aetiology of Traumatic Shock in an Australian Level 1 Trauma Centre

Emergency Medicine Australasia, Volume 38, Issue 3, June 2026.
ABSTRACT Objective Resuscitation of traumatic shock (TS) is reflexively oriented towards haemorrhage control, reflecting its contribution to early preventable mortality. While the mechanisms of shock are well established, the relative frequency of haemorrhagic, non‐haemorrhagic, indeterminate, and mixed aetiologies in blunt‐predominant cohorts is less ...
Michael Noonan, Fraser Francis‐Pester, Gerard O'Reilly, Joseph Mathew, Chris Groombridge, Dinesh Varma, Mark Fitzgerald   +6 more
wiley   +1 more source

Tissue‐retained needles in people who inject drugs: A systematic review of case reports and series on clinical presentations, complications and management

Addiction, Volume 121, Issue 6, Page 1381-1397, June 2026.
Abstract Background and aims Tissue‐retained needles from intravenous drug use can cause rare but severe complications, ranging from local to systemic infections to needle embolization. Due to the limited evidence and the lack of epidemiological studies on the issue, we systematically reviewed the literature focusing on case reports and case series on ...
Heidi Laukkala, Anna Nevalainen, Irina Rinta‐Kiikka, Samuel Heikkilä, Sisu Kiuru, Markku Sumanen, Otso Arponen, Olli Nevalainen   +7 more
wiley   +1 more source

Hospital Costs Associated With Mechanical Left Ventricular Unloading Devices During VA ECMO for Adult Cardiogenic Shock

Artificial Organs, Volume 50, Issue 6, Page 917-923, June 2026.
In a cohort of patients with cardiogenic shock supported with V‐A ECMO, the addition of left ventricular mechanical unloading was associated with higher median hospitalization costs ($390 508 vs. $320 269), longer hospital length of stay (IRR 1.06, p < 0.001), and lower mortality compared with VA ECMO alone (HR 0.62, p = 0.006).
Maxwell A. Hockstein, Joshua J. Horns, Thomas Hanff, Iosif Taleb, Craig Selzman, Stavros Drakos, Richard Nelson, Joseph E. Tonna   +7 more
wiley   +1 more source

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source

Mechanical circulatory support in patients in cardiogenenic shock

Сучасні медичні технології
Cardiogenic shock in acute myocardial infarction is a life-threatening syndrome characterized by systemic hypoperfusion that can rapidly progress to multiple organ failure and death.
V. H. Tanskyi
doaj   +1 more source

Cardiogenic shock and infection: A lethal combination [PDF]

International audienceBackground: Cardiogenic shock and sepsis are severe haemodynamic states that are frequently present concomitantly, leading to substantial mortality.
Delmas, Clément, Lim, Pascal, Lamblin, Nicolas, Khachab, Hadi, Leurent, Guillaume, Cherbi, Miloud, Marchandot, Benjamin, Vanzetto, Gerald, Levy, Bruno, Bonello, Laurent, Combaret, Nicolas, Bonnefoy, Eric, Schurtz, Guillaume, Labbé, Vincent, Harbaoui, Brahim, Merdji, Hamid, Gerbaud, Edouard, Puymirat, Etienne, Roubille, François, Lattuca, Benoît, Biendel-Picquet, Caroline   +20 more
core   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source