Results 151 to 160 of about 611,997 (371)
CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype
Advanced Science, EarlyView.Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen +18 morewiley +1 more sourceUnderweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study
Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1242-1251, December 1, 2022., 2022 Abstract Background
In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures.Jari A. Laukkanen, Setor K. Kunutsor, Jussi Hernesniemi, Jaakko Immonen, Markku Eskola, Francesco Zaccardi, Matti Niemelä, Timo Mäkikallio, Magnus Hagnäs, Jarkko Piuhola, Jukka Juvonen, Jussi Sia, Juha Rummukainen, Kari Kervinen, Juha Karvanen, Kjell Nikus, KARDIO Study Group +16 morewiley +1 more sourceKinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis
Advanced Science, EarlyView.Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu +13 morewiley +1 more sourceCorrelation of aortic valve annular plane assessment by on‐table three‐dimensional rotational angiography and preprocedural computed tomography
Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1316-1322, December 1, 2022., 2022 Abstract Objectives
To assess the correlation between the aortic valve annular plane (AVAP) obtained by preprocedural computed tomography (CT) with on‐table three‐dimensional rotational angiography (3DRA), in patients undergoing transcatheter aortic valve replacement (TAVR).Richard Tanner, Sean Murphy, Ciara Malone, Catherine McGorrian, Declan Sugrue, David Barton, Roger Byrne, Gavin Blake, Ronan Margey, Ivan P. Casserly +9 morewiley +1 more sourceMacrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis
Advanced Science, EarlyView.The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang +13 morewiley +1 more sourceCustomized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1
Advanced Science, EarlyView.Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou +9 morewiley +1 more source2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Journal of the American College of Cardiology, 2019 S. Grundy, N. Stone, Alison L. Bailey, Craig T. Beam, K. Birtcher, R. Blumenthal, L. Braun, S. D. de Ferranti, Joseph Faiella-Tommasino, D. Forman, Ronald Goldberg, P. Heidenreich, M. Hlatky, Daniel W. Jones, D. Lloyd‐Jones, Nuria Lopez-Pajares, C. Ndumele, C. Orringer, C. Peralta, J. Saseen, Sidney C. Smith, L. Sperling, S. Virani, J. Yeboah +23 moresemanticscholar +1 more source