Results 161 to 170 of about 877,301 (350)

Retracted: A Comprehensive Review on Metabolic Syndrome

open access: yesCardiology Research and Practice, 2019
Cardiology Research and Practice
doaj   +1 more source

Heart Rate Profiles During Exercise and Incident Parkinson's Disease

open access: yesAnnals of Neurology, EarlyView.
Objective To determine whether established heart rate parameters of exercise, related to cardiac autonomic function, are associated with incident Parkinson's disease, independent of both clinical and autonomic prodromal features. Methods A study of UK Biobank participants who performed a standardized bicycle exercise test (2009–2013), followed until ...
Stefan van Duijvenboden   +13 more
wiley   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

open access: yesAnnals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek   +7 more
wiley   +1 more source

Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early‐Onset Parkinsonism

open access: yesAnnals of Neurology, EarlyView.
Objective Autophagy is a fundamental biological pathway with vital roles in intracellular homeostasis. During autophagy, defective cargoes including mitochondria are targeted to lysosomes for clearance and recycling. Recessive truncating variants in the autophagy gene EPG5 have been associated with Vici syndrome, a severe early‐onset neurodevelopmental
Hormos Salimi Dafsari   +140 more
wiley   +1 more source

The rational approach to selection of anticoagulation for stroke prevention in patients with atrial fibrillation of non-valvular etiology

open access: yesСеченовский вестник, 2014
The question of how to use most eff ectively and safely drugs from the group of oral anticoagulants for prevention of thromboembolic complications (TEC) in patients with atrial fi brillation (AF) non-valvular etiology is analyzed in this paper.
D. A. Napalkov, A. A. Sokolova
doaj  

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