Results 91 to 100 of about 413,528 (329)

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]

, 2018
Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen, Arimoto, Balling, Bolignano, Cabassi, Dupont, Gaggin, Gravning, Grodin, Guisado Espartero, Haehling, Harrell, Jackson, Lassus, Lassus, Lok, Maisel, Maisel, McMurray, McMurray, Miller, Miller, Nagarajan, Park, Pascual-Figal, Pencina, Pencina, Pocock, Ponikowski, Rahimi, Rush, Shlipak, Swedberg, Tentzeris, Zamora   +34 more
core   +4 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Drug Design, Development and Therapy, 2016
Mi-Seung Shin,1 Dae Ryong Kang,2 Changsoo Kim,3 Eun Joo Cho,4 Ki-Chul Sung,5 Seok-Min Kang,6 Dong-Soo Kim,7 Seung Jae Joo,8 Seung Hwan Lee,9 Kyung-Kuk Hwang,10 Jeong Bae Park11 1Division of Cardiology, Department of Internal Medicine, Gachon University ...
Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB   +10 more
doaj  

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source

Cardiovascular–Endocrine–Metabolic Medicine: Proposing a New Clinical Sub-Specialty Amid the Cardiometabolic Pandemic

Biomolecules
Cardiovascular–Renal–Hepatic–Metabolic diseases are on the rise worldwide, creating major challenges for patient care and clinical research. Although these conditions share common mechanisms and often respond to similar treatments—such as lifestyle ...
Nikolaos Theodorakis, Maria Nikolaou, Andrew Krentz   +2 more
doaj   +1 more source

Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension. [PDF]

, 2019
Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH ...
Bhattacharya, Priyanka T., Birati, Edo Y., Chirinos, Julio A., Forfia, Paul R., Fox, Arieh L., Grandin, E. Wilson, Kawut, Steven M., Mao, Frances, Mazimba, Sula, Mazurek, Jeremy A., Menachem, Jonathan N., Smith, Kerri Akaya, Tanna, Monique S., Troutman, Gregory S., Vaidya, Anjali, Zamani, Payman   +15 more
core   +2 more sources

Bio‐Inspired Micro‐Fin‐Assisted Multi‐Modal Vascular Intervention

Advanced Science, EarlyView.
A magnetic guidewire with a micro‐fin–integrated tip is introduced for multimodal cardiovascular navigation. The micro‐fins exploit fluid drag to augment magnetic torque, enabling bifurcation traversal at 15 mT, tolerating 45° misalignment, bidirectional crawling, and buckle self‐correction.
Xu Liu, Qiang Luo, Zhuoqun Cao, Hongde Li, Xi Chen, Hong Wang, Mao Chen, Ziyu Ren, Wenqi Hu   +8 more
wiley   +1 more source

A core curriculum for the continuing professional development of nurses: Developed by the Education Committee on behalf of the Council on Cardiovascular Nursing and Allied Professions of the ESC [PDF]

, 2015
Background: The European Society of Cardiology and the Council on Cardiovascular Nursing and Allied Professions share a vision; to decrease the burden of cardiovascular disease in Europe.
Astin, Felicity, Carroll, D. L., Hinterbuchner, L., Ketchell, A., Kletsiou, E., Ruppar, T., Serafin, A., Uchmanowicz, I.   +7 more
core   +1 more source