Results 71 to 80 of about 362,252 (265)

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

open access: yesAdvanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge   +10 more
wiley   +1 more source

Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings

open access: yesAdvanced Science, EarlyView.
Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei   +8 more
wiley   +1 more source

MMP-2 and sTNF-R1 variability in patients with essential hypertension: 1-year follow-up study [PDF]

open access: yes, 2012
The aim of this study is to analyze MMP-2 and sTNF-R1 variability, potent predictors of cardiovascular events, in stable hypertensive patients during a 12-month followup.
Calabuig, Jose R.   +10 more
core   +3 more sources

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

open access: yesAdvanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim   +12 more
wiley   +1 more source

The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up The MESA Study [PDF]

open access: yes, 2014
Left ventricular (LV) trabeculation is highly variable among individuals and is increased in some diseases (e.g., congenital heart disease or cardiomyopathies), but its significance in population-representative individuals is ...
Anand   +33 more
core   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

open access: yesAdvanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu   +18 more
wiley   +1 more source

Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy [PDF]

open access: yes, 2016
No abstract ...
Arrigo   +48 more
core   +4 more sources

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

open access: yesAdvanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang   +10 more
wiley   +1 more source

Quality indicators for post-resuscitation care after out-of-hospital cardiac arrest: a joint statement from the Association for Acute Cardiovascular Care of the European Society of Cardiology, the European Resuscitation Council, the European Society of Intensive Care Medicine, and the European Society for Emergency Medicine [PDF]

open access: bronze, 2023
Johannes Grand   +17 more
openalex   +1 more source

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