Impact of dyslipidemia on cardiovascular risk stratification of hypertensive patients and association of lipid profile with other cardiovascular risk factors: results from the ICEBERG study [PDF]
Giray Kabakci1, Nevres Koylan2, Baris Ilerigelen3, Omer Kozan4, Kemalettin Buyukozturk2 on behalf of the ICEBERG Investigators1Hacettepe University, Hacettepe School of Medicine, Department of Cardiology, Ankara, Turkey; 2Istanbul University, Istanbul ...
Buyukozturk, Kemalettin+4 more
core +3 more sources
Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study [PDF]
Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary ...
Allayee, Hooman+103 more
core +1 more source
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang+12 more
wiley +1 more source
Health Digital Twins Supported by Artificial Intelligence-based Algorithms and Extended Reality in Cardiology [PDF]
Recently, significant efforts have been made to create Health Digital Twins (HDTs), digital twins for clinical applications. Heart modeling is one of the fastest-growing fields, which favors the effective application of HDTs. The clinical application of HDTs will be increasingly widespread in the future of healthcare services and has a huge potential ...
arxiv +1 more source
A New Approach in Risk Stratification by Coronary CT Angiography. [PDF]
For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks.
Budoff, Matthew J, Nakanishi, Rine
core +3 more sources
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li+21 more
wiley +1 more source
Brigitte Kazzi,1 Bairavi Shankar,1 Petal Elder-Odame,2 Lale S Tokgözoğlu,3 Lilia M Sierra-Galan,4 Erin D Michos2 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Department of Medicine, Division of ...
Kazzi B+5 more
doaj
This study shows that Foxp1 regulates the USP20–HIF1ɑ‐Hand1 pathway, controlling cardiomyocyte metabolic reprogramming, proliferation, and heart regeneration. By targeting Hand1, the downstream effector, this work suggests a promising molecular target for gene therapy of heart failure, potentially guiding the development of novel molecular ...
Yanfang Wang+19 more
wiley +1 more source
Multi-Modality Cardiac Image Computing: A Survey [PDF]
Multi-modality cardiac imaging plays a key role in the management of patients with cardiovascular diseases. It allows a combination of complementary anatomical, morphological and functional information, increases diagnosis accuracy, and improves the efficacy of cardiovascular interventions and clinical outcomes.
arxiv
Appropriateness of referrals for single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in a developing community: A comparison between 2005 and 2009 versions of ACCF/ASNC appropriateness criteria [PDF]
Appropriateness of referrals for myocardial perfusion imaging (MPI) in developing countries has not been extensively studied. Our study was conducted to describe the ordering practices of physicians and appropriateness of MPI referrals in Iran.
Alborzi, A.+7 more
core +1 more source