Results 81 to 90 of about 362,252 (265)
The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress
Advanced Science, EarlyView.This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen +18 morewiley +1 more sourceVarespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial [PDF]
, 2014 IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes ...Abraham, J, Abramson, B, Acheatel, R, Ahmed, M, Akhunova, S, Alegret, JM, Alonso-Pulpón, L, Amerena, J, Amkieh, A, Amlani, M, Anand, D, Anderson, J, Antolin, JM, Areses, EL, Arkhipov, M, Aroney, C, Arstall, M, Asfour, A, Ashchi, M, Auguadro, C, Azar, R, Balog, C, Banker, D, Barbarash, O, Barbarich, V, Bash, Dianna, Battaglia, J, Belenky, D, Benczur, B, BERNI, Andrea, Berti, S, Bertolet, B, Biasucci, LM, Black, R, Blanchard, A, Blonder, R, Bokern, MJ, Bosschaert, M, Braun-Dullaeus, R, Breedveld, RW, Brennan, Danielle M., Brilakis, E, Broadwater, S, Bronisz, M, Bronzwaer, PN, Brown, A, Brown, WV, Browne, K, Burtt, D, Camp, A, Cannon, K, Cavender, JB, Cavender, Matthew A., Cendon, AA, Cervinka, P, Chandna, H, Chandra, S, Chandrashekhar, Y, Chapidze, G, Chawla, K, Chernick, R, Chronos, N, Chumburidze, V, Collins, N, Constance, C, Corrada, E, Cortés, JM, Crowley, S, Csapo, K, Cuccia, C, Dabrowski, M, Dani, S, Dart, A, Davies, C, Delafontaine, P, Della-Siega, A, DeMets, D, Den Hartog, F, den Hartoog, M, Dengler, T, Denning, S, Derlaga, B, Devlin, G, Dezsi, C, Dinnyes, J, Dobrzycki, S, Doevendans, P, Dorsel, T, Dovgalevskiy, Y, Downes, T, Drenning, D, Drozdz, J, Drzewiecki, A, East, C, Eaton, G, Edes, I, Eich, D, Elliott, J, Ermoshkina, L, Esquivias, GB, Farshid, A, Faynyk, A, Fedele, F, Fernández, JD, Ferrier, L, Feskov, O, Fineschi, M, Franco, SN, French, W, Frey, N, Fulwani, M, Gebel, J, Genth-Zotz, S, Genís, AB, Gessek, J, Gielen, S, Gillespie, E, Gniot, J, Go, B, Goloborodko, B, Goloshchekin, B, González, MJ, Gordeev, I, Gormaz, CL, Gosselin, G, Goswami, R, Goya, IL, Gunalingam, B, Gupta, S, Guseva, G, Haldis, T, Haltern, G, Harding, S, Hart, H, Heckman, MJ, Hengstenberg, C, Henry, P, Hermans, W, Herrman, J, Heuer, H, Horak, D, Horowitz, J, Hubacek, J, Huff, C, Hulinsky, V, Hutyra, M, Huynh, T, Ilmer, B, Ingelmo, JM, Janik, M, Jarne, EF, Jay, D, Jukema, J. Wouter, Kahali, D, Kancz, S, Karpenko, O, Karpenko, Y, Kashou, H, Kastelein, John J. P., Katerenchuk, O, Katzan, I, Kedhi, E, Keijzers, M, Khaisheva, L, Khintibidze, I, Kie, SH, Kiss, R, Kleiman, N, Klein, G, Klimovic, T, Klimsa, Z, Kmetzo, J, Kobulia, B, Kochmanski, M, Koenig, W, Koenig, Wolfgang, Kokis, A, Kopytsya, M, Korban, E, Kornacewicz-Jach, Z, Kostenko, V, Kovacs, Z, Koval, O, Kozhukhov, S, Kozlowski, A, Kraiz, I, Kreuzer, J, Kukuy, E, Kuznetsov, V, Lago, VN, Lai, C, Lamas, G, Lambert, C, Lapp, H, Lauer, M, Lavi, S, Leithäuser, B, Lenderink, T, Leschke, M, Libis, R, Lieberman, S, Liem, A, Lincoff, A. Michael, Linev, K, Lioy, E, Lochridge, S, Lok, D, Loussararian, A, Lu, D, Lupkovics, G, MacDonald, L, Madej, A, Magagnini, E, Mahar, L, Maly, M, Mamatsashvili, M, Mann, J, Marenzi, G, Markov, V, Marso, S, Martin Mde, M, Martin, IH, Martin, L, Mayer, O, McCullum, K, Megreladze, I, Mennuni, M, Menon, Venu, Merenda, R, Merkely, B, Miekus, P, Mikhin, V, Minisi, A, Miranda, JM, Monhart, Z, Monraats, P, Montero, JS, Moretti, L, Motovska, Z, Movahed, M, Mudra, H, Mukherjee, A, Muller, G, Musial, W, Möllmann, H, Nagy, A, Nambi, Vijay, Nava, JS, Navarro, MJ, Nicholls, Stephen J., Nierop, P, Nissen,, Nogai, K, Oei, F, Ortiz, AI, Ovcharenko, E, Paradis, JM, Parikh, K, Parker, J, Peñaranda, AS, Pfeffer, M, Piscione, F, Pleva, L, Pluta, W, Polasek, P, Polgar, P, Polk, D, Pollock, S, Ponikowski, P, Prasad, C, Prati, F, Premchand, R, Prokhorov, O, Psuja, P, Pudil, R, Pérez, MB, Rajput, R, Ramaswamy, G, Rassi, A, Reichert, P, Rekosz, J, Rezkalla, S, Richardson, J, Rivera, E, Robertson, R, Rodes-Cabau, J, Roleau, J, Romero, AJ, Romo, AI, Ronaszeki, A, Ronner, E, Rosenberg, M, Rosenson, Robert S., Rotterova, H, Rubio, AM, Ruda, M, Rudenko, L, Runquist, L, Rynkiewicz, A, Sangiorgi, G, Sanmartín, M, Sanz, M, Sanz, RR, Saucedo, J, Schwartz, G, Schwartz, Gregory G., Seigel, P, Semenka, J, Senaratne, M, Sereg, M, Shaburishvili, T, Shah, A, Shalnev, V, Shishehbor, M, Shvarts, Y, Silverman, P, Simanenkov, V, Simonyi, G, Skelding, K, Soriano, FR, Speciale, G, Spinar, J, Stellbrink, C, Steven E., Hennekens C, Stillabower, M, Strain, J, Strasser, R, Sultan, P, Suriano, P, Tans, JG, Testa, R, Thadani, U, Thompson, P, Timofeev, A, Tolerico, P., Treasure, C, Trip, MD, Trivedi, S, Troquay, R, Uchino, K, Ujda, M, Urbano, RH, Vadaganelli, P, Vakaliuk, I, Valgimigli, M, van de Wetering, ML, van der Heijden, R, van Gaal, W, van Wijk, L, Veen, G, Vertes, A, Vest, A, Vijay, N, Vishnevsky, A, Voehringer, HF, Volkova, E, Wachter, R, Werner, N, White, M, Wiley, M, Wilkins, G, Williams, J, Witkowski, A, Wright, R. Scott, Wysokinski, A, Youssef, G, Zadra, R, Zateyshchikov, D, Zishiri, E, Zubiri, JJ +369 morecore +1 more source[Bibliometric analysis of peruvian scientific production in cardiology and cardiovascular medicine].
Archivos peruanos de cardiologia y cirugia cardiovascular, 2021 Objetivo. Determinar las características y la tendencia de los artículos publicados sobre cardiología y medicina cardiovascular en el contexto peruano, y comprender cómo ha cambiado a lo largo de los años. Materiales y métodos. Se realizó un estudio bibliométrico de artículos originales publicados hasta el año 2020 por autores peruanos en revistas ...Vargas-Fernández, Rodrigo, Visconti-Lopez, Fabriccio J., Barón-Lozada, Francisco A., Basualdo-Meléndez, Gianfranco W. +3 moreopenaire +2 more sourcesCCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype
Advanced Science, EarlyView.Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen +18 morewiley +1 more sourceA time of accelerated change in academic cardiovascular medicine
Journal of the American College of Cardiology, 2004 With the vast epidemic of vascular disease predicted to be the leading cause of death and disability by a growing margin over the next 30 years, academic medical centers with cardiology training programs have a special responsibility. Given the dramatic advances of biotechnology in producing highly effective but expensive strategies of prevention and ...Robert M. Califf, Pamela S. Douglas, Thomas J. Ryan, Pascal J. Goldschmidt-Clermont +3 moreopenaire +2 more sourcesEBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes
Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang +9 morewiley +1 more sourceMacrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis
Advanced Science, EarlyView.The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang +13 morewiley +1 more sourceNovel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions - A review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology [PDF]
, 2016 The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of
huge efforts in understanding pathogeneticmechanisms and in developing effective therapies that have transformed this ...Angelini, Annalisa, Arcaro, Alessia, Chimenti, Cristina, Crotti, Lia, Giordano, Carla, Mancardi, Daniele, Pirozzi, Flora, Tocchetti, Carlo G., Torella, Daniele +8 morecore +5 more sourcesREDUCE-IT USA: Results From the 3146 Patients Randomized in the United States. [PDF]
, 2020 BackgroundSome trials have found that patients from the United States derive less benefit than patients enrolled outside the United States. This prespecified REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl - Intervention Trial ...Ballantyne, Christie M, Bhatt, Deepak L, Brinton, Eliot A, Budoff, Matthew J, Chung, Mina K, Doyle, Ralph T, Gibson, C Michael, Giugliano, Robert P, Granowitz, Craig, Jacobson, Terry A, Jiao, Lixia, Juliano, Rebecca A, Ketchum, Steven B, Miller, Michael, Olshansky, Brian, REDUCE-IT Investigators, Steg, Ph Gabriel, Tardif, Jean-Claude +17 morecore +1 more source
