Results 81 to 90 of about 61,574 (301)

Sudden cardiac death in inherited cardiomyopathy [PDF]

, 2017
Cardiomyopathy is an important cause of sudden cardiac death particularly in adolescents and young adults. The risk of sudden cardiac death varies between individual cardiomyopathies and is dependent on the severity of disease, age and gender.
Collis, R, Elliott, PM
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial

ESC Heart Failure
Background Dilated cardiomyopathy (DCM) is a leading cause of heart failure, particularly in younger individuals. Low physical strength is a global risk factor for cardiovascular mortality, and physical activity and a healthy lifestyle have been shown to
Farbod Sedaghat‐Hamedani, Ali Amr, Theresa Betz, Elham Kayvanpour, Christoph Reich, Reto Wettstein, Oliver Heinze, Isabell Mohr, Regina Krisam, Anja Sander, Christina Klose, Birgit Friedmann‐Bette, Norbert Frey, Benjamin Meder   +13 more
doaj   +1 more source

Takotsubo cardiomyopathy and sepsis: a systematic review [PDF]

, 2017
Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of the left ventricle. It is usually related to physical or emotional stress.
Agarwal V, Costantino Ciallella, Geng S, Hutan Ashrafian, Lee S, Mariarosaria Aromatario, Maron BJ, Odigie-Okon E, Pullara A, Sarullo FM, Sato H, Sharkey SW, Sian Harding, Simone Cappelletti, Thanos Athanasiou, Xu RH   +15 more
core   +1 more source

Implementation of First‐Line Rapid Genome Sequencing for Children in Pediatric and Cardiac Intensive Care Units

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Substantial data supports the use of rapid exome and genome sequencing (rES/rGS) in Neonatal Intensive Care Units (NICU), but fewer studies have examined the impact of rES/rGS in other pediatric critical care units. We evaluated the impact on diagnostic yield and time to diagnosis following a single‐center hospital policy change allowing ...
Alexandra C. Keefe, Abbey A. Scott, Lukas Kruidenier, Jessie Conta, Darci L. Sternen, Sarah V. Clowes Candadai, Shannon M. Stasi, Julia Parish‐Morris, Megan Sikes, Margaret P. Adam, Anita E. Beck, Jennifer C. Hayek, Ian Glass, James T. Bennett, Ghayda Mirzaa, Paul Kruszka, Britt Johnson, Kirsty McWalter, Deborah Copenheaver, Bethany Friedman, Michael Bamshad, Katrina M. Dipple, Tara L. Wenger   +22 more
wiley   +1 more source

Unraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan

Scientific Reports
Pediatric cardiomyopathies are mostly attributed to variants in sarcomere-related genes. Unfortunately, the genetic architecture of pediatric cardiomyopathies has never been previously studied in Jordan.
Bilal Azab, Dunia Aburizeg, Sherin T. Shaaban, Weizhen Ji, Lina Mustafa, Nooredeen Jamal Isbeih, Amal Saleh Al-Akily, Hashim Mohammad, Lauren Jeffries, Mustafa Khokha, Saquib A. Lakhani, Iyad Al-Ammouri   +11 more
doaj   +1 more source

Identification of gene co-regulatory modules and associated elements involved in degenerative heart disease [PDF]

, 2009
Background Cardiomyopathies, degenerative diseases of cardiac muscle, are among the leading causes of death in the developed world. Microarray studies of cardiomyopathies have identified up to several hundred genes that significantly alter their ...
Charles G Danko, Arkady M Pertsov, JA Towbin, JD Barrans, F Wittchen, J Hwang, MM Kittleson, F Tan, R Grzeskowiak, JL Hall, AS Barth, MB Eisen, VR Iyer, E Segal, M Gupta, OV Kel-Margoulis, MA Beer, R Edgar, R Gentleman, WE Johnson, AI Su, R Development Core Team, H Wakaguri, TJP Hubbard, G Dennis, C Danko, A Subramanian, X Xie, RCG Holland, DW Jeong, C Kioussi, PK Bhavsar, KA Dellow, MS Parmacek, R Bassel-Duby, MS Parmacek, S Malik, TH Christensen, H Rindt, J Tian, BJ Wilkins, LA Megeney, T Sugimoto, M Flesch, J Wang   +44 more
core   +2 more sources

Non-invasive stroke volume assessment during cardiopulmonary exercise testing provides additional insight beyond O2-pulse in hypertrophic cardiomyopathy

Scientific Reports
In hypertrophic cardiomyopathy (HCM), cardiopulmonary exercise testing (CPET) is considered the gold standard for assessing exercise tolerance, with O2-pulse commonly used as a surrogate for stroke volume (SV). However, because SV reduction can be masked
Massimo Mapelli, Nikita Baracchini, Nicola Campana, Teresa Maria Capovilla, Alessandro Nava, Elisabetta Salvioni, Carlo Vignati, Filippo Maria Rubbo, Damiano Magrì, Beatrice Pezzuto, Irene Mattavelli, Nicolò Capra, Simona Costantino, Fiorella Puttini, Cosimo Carriere, Irena Tavčar, Maddalena Rossi, Christian Cadeddu Dessalvi, Robin Willixhofer, Marco Merlo, Gianfranco Sinagra, Piergiuseppe Agostoni   +21 more
doaj   +1 more source

cMRI-BED: A novel informatics framework for cardiac MRI biomarker extraction and discovery applied to pediatric cardiomyopathy classification [PDF]

, 2015
Background\ud Pediatric cardiomyopathies are a rare, yet heterogeneous group of pathologies of the myocardium that are routinely examined clinically using Cardiovascular Magnetic Resonance Imaging (cMRI).
Prahlad G Menon, Shobhit Madan, Vanathi Gopalakrishnan   +2 more
core   +3 more sources