Results 91 to 100 of about 91,175 (237)

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Advanced Genetics, EarlyView.
Here, causal relations are examined between 2940 plasma proteins and 19 cardiovascular diseases (CVD) using a human genetics‐based method. 218 proteins are found whose blood levels influence CVD risks, with about half being new discoveries and largely confirmed in an independent cohort.
Chen Li, Nicolas De Jay, Shan‐Shan Zhang, Xin Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski, Ching‐Pin Chang, Joseph C. Maranville, Emily R. Holzinger, Erika M. Kvikstad   +13 more
wiley   +1 more source

Myocardial Perfusion Defects in Hypertrophic Cardiomyopathy Mutation Carriers

Journal of the American Heart Association, EarlyView., 2021
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature of hypertrophic cardiomyopathy (HCM). Although most evident in hypertrophied or scarred segments, reduced MBF can occur in apparently normal segments.
Rebecca K. Hughes, Claudia Camaioni, João B. Augusto, Kristopher Knott, Ellie Quinn, Gabriella Captur, Andreas Seraphim, George Joy, Petros Syrris, Perry M. Elliott, Saidi Mohiddin, Peter Kellman, Hui Xue, Luis R. Lopes, James C. Moon   +14 more
wiley   +1 more source

Asymptomatic Hypertrophic Cardiomyopathy: Diagnosis and Therapy [PDF]

, 2017
Fuentes, V L, Wilkie, L J
core   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Simultaneous T1, T2, and T1ρ mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To develop a cardiac MR fingerprinting (cMRF) approach using deep image prior reconstruction (DIP) to simultaneously map T1, T2, and T1ρ, and assess T1ρ in healthy subjects and patients with areas of enhancement on late gadolinium enhancement.
Sydney Kaplan, Gastao Lima da Cruz, Chaitanya Madamanchi, Venkatesh L. Murthy, Scott Swanson, Jesse Hamilton, Nicole Seiberlich   +6 more
wiley   +1 more source

Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold.
Dongyue Si, Michael G. Crabb, Simon J. Littlewood, Karl P. Kunze, Juliet Varghese, Katherine Binzel, Mahmood Khan, Orlando P. Simonetti, Claudia Prieto, René M. Botnar   +9 more
wiley   +1 more source

Risk factors associated with sudden death vs. congestive heart failure or arterial thromboembolism in cats with hypertrophic cardiomyopathy [PDF]

, 2016
Borgeat, K A, Brodbelt, D C, Connolly, D J, Fuentes, V L, Payne, J R   +4 more
core   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, EarlyView.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source