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The Lancet, 1998
Hypertrophic cardiomyopathy is a common genetically transmitted disease, defined clinically by the presence of unexplained left ventricular hypertrophy. The disease has a varied clinical course and outcome; many patients have little or no discernible cardiovascular symptoms, whereas others have profound exercise limitation and recurrent arrhythmias ...
Perry, Elliott, William J, McKenna
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Hypertrophic cardiomyopathy is a common genetically transmitted disease, defined clinically by the presence of unexplained left ventricular hypertrophy. The disease has a varied clinical course and outcome; many patients have little or no discernible cardiovascular symptoms, whereas others have profound exercise limitation and recurrent arrhythmias ...
Perry, Elliott, William J, McKenna
openaire +3 more sources
JAAPA, 2018
Hypertrophic cardiomyopathy is the most common inherited cardiovascular disease. It is characterized by increased ventricular wall thickness and is highly complex due to its heterogeneous clinical presentation, several phenotypes, large number of associated causal mutations and broad spectrum of complications.
Juan José, Santos Mateo +2 more
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Hypertrophic cardiomyopathy is the most common inherited cardiovascular disease. It is characterized by increased ventricular wall thickness and is highly complex due to its heterogeneous clinical presentation, several phenotypes, large number of associated causal mutations and broad spectrum of complications.
Juan José, Santos Mateo +2 more
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Circulation
AIM The "2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy" provides recommendations to guide clinicians in the management of patients with hypertrophic cardiomyopathy.
S. Ommen +21 more
semanticscholar +1 more source
AIM The "2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy" provides recommendations to guide clinicians in the management of patients with hypertrophic cardiomyopathy.
S. Ommen +21 more
semanticscholar +1 more source
Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy.
New England Journal of MedicineBACKGROUND One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction ...
M. Maron +32 more
semanticscholar +1 more source
Cardiology in the Young, 1977
AbstractHypertrophic cardiomyopathy is a common, inherited heart disease with a heterogeneous clinical presentation and natural history. Recently, advances in diagnosis and treatment options have been instrumental in decreasing the frequency of adverse clinical events; however, complete elimination of sudden cardiac death still remains an elusive gain.
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AbstractHypertrophic cardiomyopathy is a common, inherited heart disease with a heterogeneous clinical presentation and natural history. Recently, advances in diagnosis and treatment options have been instrumental in decreasing the frequency of adverse clinical events; however, complete elimination of sudden cardiac death still remains an elusive gain.
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Acta Pharmacologica et Toxicologica, 1986
Abstract: Hypertrophic cardiomyopathy is characterized by a hypertrophic and non‐dilated left ventricle with disproportionate involvement of the intraventricular septum compared to the free walls, and by varying degrees of outflow obstruction during systole. Its symptoms and clinical course, pathogenesis and treatment are briefly discussed.
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Abstract: Hypertrophic cardiomyopathy is characterized by a hypertrophic and non‐dilated left ventricle with disproportionate involvement of the intraventricular septum compared to the free walls, and by varying degrees of outflow obstruction during systole. Its symptoms and clinical course, pathogenesis and treatment are briefly discussed.
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Current Treatment Options in Cardiovascular Medicine, 2002
When an individual is diagnosed with hypertrophic cardiomyopathy (HCM), all relatives potentially affected by Mendelian autosomal-dominant inheritance should be evaluated with an electrocardiogram (ECG) and echocardiogram. Genetic testing should be considered in high-risk mutations where there are diagnostic uncertainties.
Elijah R., Behr, William J., McKenna
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When an individual is diagnosed with hypertrophic cardiomyopathy (HCM), all relatives potentially affected by Mendelian autosomal-dominant inheritance should be evaluated with an electrocardiogram (ECG) and echocardiogram. Genetic testing should be considered in high-risk mutations where there are diagnostic uncertainties.
Elijah R., Behr, William J., McKenna
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Clinical Course and Management of Hypertrophic Cardiomyopathy
New England Journal of Medicine, 2018Hypertrophic Cardiomyopathy HCM is the most common genetic disorder of the heart, with 1 case per 200 to 500 persons, and often remains clinically silent.
B. Maron
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Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy
Annals of Internal Medicine, 2019Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease that is caused by mutations in genes encoding sarcomere proteins (1, 2) and has an autosomal dominant pattern of inheritance.
S. Heitner +9 more
semanticscholar +1 more source
Current Treatment Options in Cardiovascular Medicine, 1999
The degree of clinical expression of both obstructive and nonobstructive hypertrophic cardiomyopathy (HCM) is widely variable. Many patients with HCM are asymptomatic or minimally symptomatic. Most patients with mild or moderate HCM respond well to medical therapy, but medical therapy in patients with severe disease is only marginally beneficial.
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The degree of clinical expression of both obstructive and nonobstructive hypertrophic cardiomyopathy (HCM) is widely variable. Many patients with HCM are asymptomatic or minimally symptomatic. Most patients with mild or moderate HCM respond well to medical therapy, but medical therapy in patients with severe disease is only marginally beneficial.
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