Results 71 to 80 of about 46,771 (265)

Syncope with QT‐interval prolongation and T‐wave inversion in anterior and inferior leads: Foreboder of a life‐threatening condition?

Annals of Noninvasive Electrocardiology, Volume 28, Issue 1, January 2023., 2023
The patient’s ECG exhibited QT‐interval prolongation with T‐wave inversion in anterior and inferior leads that, together with CT‐pulmonary angiography findings, strongly suggested PE. This ECG pattern is crucial for diagnosing PE. Abstract Even though patients with pulmonary embolism usually present with respiratory distress and tachycardia, the ...
Jing‐Xiu Li, Jing Wang, Xue‐Qi Li, Min Gao   +3 more
wiley   +1 more source

Segmentation of the Myocardium on Late-Gadolinium Enhanced MRI based on 2.5 D Residual Squeeze and Excitation Deep Learning Model [PDF]

arXiv, 2020
Cardiac left ventricular (LV) segmentation from short-axis MRI acquired 10 minutes after the injection of a contrast agent (LGE-MRI) is a necessary step in the processing allowing the identification and diagnosis of cardiac diseases such as myocardial infarction.
arxiv  

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Clinical profile, short and long‐term outcomes of non‐ischaemic cardiogenic shock: A FRENSHOCK sub‐analysis

ESC Heart Failure, EarlyView.
Abstract Aims Although predominant in routine practice, non‐ischaemic cardiogenic shock (NICS) remains underrepresented in past studies, mainly focused on ischaemic cardiogenic shock (CS). This study aims to describe the current NICS picture and define its independent correlates of short‐ and long‐term outcomes.
Miloud Cherbi, François Roubille, Edouard Gerbaud, Eric Bonnefoy, Nicolas Lamblin, Laurent Bonello, Bruno Levy, Pascal Lim, Hamid Merdji, Meyer Elbaz, Hadi Khachab, Jeremy Bourenne, Marie‐France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Nicolas Combaret, Benoit Lattuca, Guillaume Leurent, Etienne Puymirat, Clément Delmas   +20 more
wiley   +1 more source

The genetics of hypertrophic cardiomyopathy

Global Cardiology Science and Practice, 2018
Hypertrophic cardiomyopathy (HCM) is most commonly transmitted as an autosomal dominant trait, caused by mutations in genes encoding cardiac sarcomere proteins. Other inheritable causes of the disease include mutations in genes coding for proteins important in calcium handling or that form part of the cytoskeleton. At present, the primary clinical role
Akhtar, M, Elliott, P
openaire   +5 more sources

CARDIOMYOPATHY: The diagnosis of hypertrophic cardiomyopathy [PDF]

Heart, 2001
Although the pathology of hypertrophic cardiomyopathy (HCM) was first described by French pathologists in the mid 19th century, it remained for the virtually simultaneous reports of Brock and Teare in England some 43 years ago to bring modern attention to this fascinating entity.1 2 Subsequent to these surgical1 and pathological2 observations, there ...
openaire   +3 more sources

Trametinib alters contractility of paediatric Noonan syndrome‐associated hypertrophic myocardial tissue slices

ESC Heart Failure, EarlyView.
Abstract Aims No curative treatment is available for RASopathy‐associated childhood‐onset hypertrophic cardiomyopathy (RAS‐CM). Preclinical data and individual reports suggest a beneficial effect of small molecules targeting the RAS–mitogen‐activated protein (MAP) kinase (MAPK) pathway in severely affected RAS‐CM patients.
Jules Hamers, Payel Sen, Sarala Raj Murthi, Laura Papanakli, Maria von Stumm, Francesca Baessato, Julie Cleuziou, Christian Meierhofer, Peter Ewert, Andreas Dendorfer, Daphne Merkus, Cordula M. Wolf   +11 more
wiley   +1 more source

Long‐term changes in body weight and serum cholesterol in heart transplant recipients

Clinical Transplantation, Volume 36, Issue 12, December 2022., 2022
Abstract Introduction Long‐term changes in weight and blood lipids beyond 12 months after heart transplantation are largely unknown. We quantified changes in weight, body mass index (BMI), blood cholesterol, and triglycerides in heart transplant recipients (HTRs) during the 36 months after transplantation, and we assessed the influence of statin ...
Kyoko Miura, Regina Yu, Timothy R Entwistle, Scott C McKenzie, Adèle C Green   +4 more
wiley   +1 more source

Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis

Journal of Nanobiotechnology
Background Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death.
Xueli Zhao, Yuze Qin, Bowen Li, Yue Wang, Jiao Liu, Bo Wang, Jia Zhao, Jiaqi Yin, Lanlan Zhang, Jing Li, Junzhe Huang, Kun Chen, Liwen Liu, Yuanming Wu   +13 more
doaj   +1 more source