Results 101 to 110 of about 347,198 (324)

Idiopathic restrictive cardiomyopathy.

, 1984
This report details the clinical, hemodynamic, and morphologic data from four patients 59 to 77 years old (mean 66) with a primary restrictive cardiomyopathy.
M C Fishbein, R J Siegel, P K Shah
core   +1 more source

A Volume Challenge Reveals the Diagnosis of Pediatric Restrictive Cardiomyopathy

, 2022
A healthy 11-year-old girl presented with exercise intolerance of unclear etiology, and her physical exam was notable for a 3/6 systolic ejection murmur at the left upper sternal border with radiation to the back.
Elyssa Cohen, T. Marsha Ma, Ma, T. Marsha, Cohen, Elyssa, Conor P. O’Halloran, Paul Tannous, O'Halloran, Conor P., Philip T. Thrush, Tannous, Paul, Thrush, Philip T.   +9 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

An unusual ECG pattern in restrictive cardimyopathy

Indian Heart Journal, 2015
Restrictive cardiomyopathy is the least common type of primary cardiomyopathies. Electrocardiographic recording is abnormal in 99% of patients with RCM. Biatrial enlargement, obliquely elevated ST segment with notched or biphasic late peaking T waves are
M. Selvaganesh, A.S. Arul, S. Balasubramanian, N. Ganesan, S. Naina Mohammed, G.S. Sivakumar, S.R. Veeramani, P. Jeyasingh, S. Sathishkumar, S. Selvaraju   +9 more
doaj   +1 more source

MYH7 Mutations in Restrictive Cardiomyopathy

JACC: Advances
Restrictive cardiomyopathy (RCM) is a rare cardiac disease characterized by impaired ventricular filling and relaxation, with preserved systolic function. This study investigates the genetic basis of RCM and its impact on clinical outcomes, particularly heart transplantation (HTx).The aim of the study was to identify genetic variations associated with ...
Zhao, Yiqi, Liu, Shun, Mo, Han, Hua, Xiumeng, Chen, Xiao, Zhang, Yue, Wang, Weiteng, Zhao, Qian, Song, Jiangping   +8 more
openaire   +2 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Human Fibroblast‐Myeloid cell tissue atlas across lung, synovium, skin and heart

Arthritis &Rheumatology, Accepted Article.
Background The availability of single‐cell RNA sequencing (scRNAseq data) in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy

Circulation: Cardiovascular Genetics, 2017
Background— Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy characterized by impaired diastolic ventricular function resulting in a poor clinical prognosis.
N. Tucker, Micheal A. McLellan, Dongjian Hu, Jiangchuan Ye, Victoria A. Parsons, Robert W. Mills, S. Clauss, E. Dolmatova, Marisa A. Shea, D. Milan, N. Scott, M. Lindsay, S. Lubitz, I. Domian, J. Stone, Honghuang Lin, P. Ellinor   +16 more
semanticscholar   +1 more source

Titin mutation in familial restrictive cardiomyopathy

, 2014
BACKGROUND: Familial restrictive cardiomyopathy (RCM) caused by a single gene mutation is the least common of the inherited cardiomyopathies. Only a few RCM-causing mutations have been described.
Gordon, P.M.K., Pras, E., Polak-Charcon, S., Arad, M., Konen, E., Geiger, D., Freimark, D., Weissbrod, O., Gerull, B., Gramlich, M., Yoskovitz, G., Feinberg, M.S., Afek, A., Sela, B.A., Thierfelder, L., Peled, Y.   +15 more
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source