Results 251 to 260 of about 347,198 (324)

Cardiac abnormalities in a young athlete with severe pectus excavatum: a case report of a diagnostic loop between anatomical distortion and cardiomyopathy. [PDF]

Eur Heart J Case Rep
Mapelli M, Rubbo FM, Ragazzoni GL, Moscatelli S, Certini P, Conte E, Pontone G, Agostoni P.   +7 more
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

The evolving landscape of restrictive cardiomyopathy treatment: clinical trial trends and future directions. [PDF]

Front Cardiovasc Med
Deng B, Liu W.
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Association between statin use and major adverse cardiovascular events in patients with chronic kidney disease and cardiomyopathy: A retrospective case-control study. [PDF]

Medicine (Baltimore)
Qiu W, Gao W, Li L, Guo X, Liu D, Liu W, Yang X.   +6 more
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Novel FLNC and TGFB3 Mutations in Early Onset Familial Atrial Fibrillation With Diastolic Dysfunction. [PDF]

JACC Case Rep
Xu H, Li Y, Niu X, Chen K, Liu T, Fu H.
europepmc   +1 more source

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

The Journal of Physiology, EarlyView.
Abstract figure legend We present a shape modelling‐based morphological analysis of sex differences in cardiac anatomy. We conduct our analysis on 456 healthy subjects from the UK Biobank (227M/229F) to uncover sex‐based differences in healthy cardiac morphology.
Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck   +4 more
wiley   +1 more source

Supranormal Ejection Fraction as a Clinical Red Flag: Differentiating Hemodynamic Stress From Intrinsic Cardiomyopathy in Heart Failure. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Chen Y, Su X, Jiang J, Tang J, Qiu Z, Yang W, Jin W.   +6 more
europepmc   +1 more source

Electrocardiographic Correlates of Myocardial Remodeling After Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, EarlyView.
Christian Toquica, Amulya Gupta, Tucker Morey, Christopher J. Harvey, Seth H. Sheldon, Madhu Reddy, Amit Noheria   +6 more
wiley   +1 more source