Results 101 to 110 of about 607,470 (403)

Role of Implantable Cardioverter Defibrillators in the Treatment of Hypertrophic Cardiomyopathy [PDF]

, 2005
Hypertrophic cardiomyopathy (HCM) is an important cardiovascular disease with sudden cardiac death as the most devastating presentation. Implantable cardioverter defibrillators (ICD) are the optimal therapy for prevention of sudden death from ventricular
Francis, Johnson, Ghosh, Joydeep, Maron, Barry J.   +2 more
core   +1 more source

An arcane cardiomyopathy [PDF]

Netherlands Heart Journal, 2014
Last February, the Lancet and the New England Journal of Medicine almost simultaneously published two interesting case reports on an arcane cardiomyopathy [1, 2]. The New York Times drew attention to these papers in their Health Section as ‘A Medical Mystery Solved’. A 55-year-old man is described.
openaire   +3 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

Nature Communications, 2020
Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been associated with DCM, but common variant studies of the disease have yielded few associated loci.
J. Pirruccello, A. Bick, Minxian Wang, M. Chaffin, S. Friedman, Jie Yao, Xiuqing Guo, B. Venkatesh, K. Taylor, W. Post, S. Rich, J. Lima, J. Rotter, A. Philippakis, S. Lubitz, P. Ellinor, A. Khera, S. Kathiresan, Krishna G. Aragam   +18 more
semanticscholar   +1 more source

Takotsubo cardiomyopathy and sepsis: a systematic review [PDF]

, 2017
Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of the left ventricle. It is usually related to physical or emotional stress.
Agarwal V, Costantino Ciallella, Geng S, Hutan Ashrafian, Lee S, Mariarosaria Aromatario, Maron BJ, Odigie-Okon E, Pullara A, Sarullo FM, Sato H, Sharkey SW, Sian Harding, Simone Cappelletti, Thanos Athanasiou, Xu RH   +15 more
core   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

Plasma Metabolites–Based Prediction in Cardiac Surgery–Associated Acute Kidney Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Cardiac surgery–associated acute kidney injury (CSA‐AKI) is a common postoperative complication following cardiac surgery. Currently, there are no reliable methods for the early prediction of CSA‐AKI in hospitalized patients.
Hao Cui, Songren Shu, Yuan Li, Xin Yan, Xiao Chen, Zujun Chen, Yuxuan Hu, Yuan Chang, Zhenliang Hu, Xin Wang, Jiangping Song   +10 more
doaj   +1 more source

Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases.

European Heart Journal, 2016
In this paper the Working Group on Myocardial and Pericardial Disease proposes a revised definition of dilated cardiomyopathy (DCM) in an attempt to bridge the gap between our recent understanding of the disease spectrum and its clinical presentation in ...
Y. Pinto, P. Elliott, E. Arbustini, Y. Adler, A. Anastasakis, M. Böhm, D. Duboc, J. Gimeno, P. De Groote, M. Imazio, S. Heymans, K. Klingel, M. Komajda, G. Limongelli, A. Linhart, J. Mogensen, J. Moon, P. Pieper, P. Seferovic, S. Schueler, J. Zamorano, A. Caforio, P. Charron   +22 more
semanticscholar   +1 more source

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study) [PDF]

, 2012
<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with ...
Boswood, A., Braz-Ruivo, L., Culshaw, G.J., Dukes-McEwan, J., Estrada, A., French, A.T., Gordon, S.G., Loureiro, J., O'Grady, M.R., O'Sullivan, M.L., Oyama, M.A., Patteson, M., Smith, A., Summerfield, N.T., Watson, P.J., Willis, R.   +15 more
core   +1 more source

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis, Einollah Sarikhani, Vrund Patel, Dhivya Pushpa Meganathan, Leah Sadr, Anum Tahir, Zeinab Jahed, Padmini Rangamani   +7 more
wiley   +1 more source