Results 141 to 150 of about 276,376 (316)

Enhancing explainability in clinical deep-learning models: Latent-space variable decoding is superior to gradient-weighted class activation mapping

Heart Rhythm O2
Background: Deep-learning models designed to assist with clinical decision making abound in cardiology. However, the “black box” nature of these models limits physicians’ ability to use them to cross-check clinical gestalt when evaluating model ...
Richard T. Carrick, MD, PhD, Ethan J. Rowin, MD, Alessio Gasperetti, MD, PhD, Christopher Madias, MD, Martin Maron, MD, Katherine C. Wu, MD   +5 more
doaj   +1 more source

Peripartum cardiomyopathy: a review

, 2012
Michael CapriolaThomasville Medical Center, Department of Emergency Medicine, Thomasville Medical Center, Thomasville, NC, USAAbstract: Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy of unclear etiology affecting women ...
Capriola M
core  

The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy

, 2016
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection.
Heymans, Stephane, Eriksson, Urs, Lehtonen, Jukka, Cooper, Leslie T., Jr.   +3 more
core   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Simultaneous optical recording of action potentials and calcium transients in cardiac single cells differentiated from type 1 CPVT-iPS cells

Frontiers in Physiology
Numerous reports investigating channelopathies, including Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), have successfully reproduced using cardiomyocytes (CMs) differentiated from human induced pluripotent stem cells (hiPSCs).
Tadashi Takaki, Tadashi Takaki, Tadashi Takaki, Norihisa Tamura, Norihisa Tamura, Kenichi Imahashi, Kenichi Imahashi, Tomoyuki Nishimoto, Tomoyuki Nishimoto, Yoshinori Yoshida, Yoshinori Yoshida   +10 more
doaj   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

therapeautic management of diabetic cardiomyopathy

Diabetic cardiomyopathy is the presence of a disorder in the heart muscle in people who have diabetes, which in most cases ultimately leads to heart failure.
Otuoniyo, Oghene-Ruona
core  

Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan, Diane Morfin, Marion Bernetiere, Marie Fauchet, Noël Peretti, Bérénice Segrestin, Pierre Poinsot   +6 more
wiley   +1 more source

Treatment of Cardiomyopathies

, 1984
In order to advise rational treatment it is necessary to define and to classify the conditions known as cardiomyopathies. Cardiomyopathies are defined as “Heart Muscle Diseases of Unknown Causes” to distinguish them from myocardial diseases due to disorders of other systems; the “Specific Heart Muscle Diseases”.
openaire   +2 more sources

Serum prealbumin and disease progression in patients with wild-type Transthyretin Cardiomyopathy on treatment with Tafamidis.

reservedSerum transthyretin (sTTR) is the precursor protein of wild type transthyretin amyloid cardiomyopathy (ATTRwt-CM) and the biological target of tafamidis.
BALDAN, MARCO
core