Results 71 to 80 of about 311,439 (263)

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Mutation of Mitochondrial DNA G13513a Presenting with Leigh Syndrome, Wolff-Parkinson-White Syndrome and Cardiomyopathy

, 2011
Mutation of mitochondrial DNA (mtDNA) G13513A, encoding the ND5 subunit of respiratory chain complex I, can cause mitochondrial encephalopathy with lactic acidosis and stroke -like episodes (MELAS) and Leigh syndrome.
WANG, SHI-BING;WENG, WEN-CHIN;LEE, NI-CHUNG;HWU, WUH-LIANG;FAN, PI-CHUAN;LEE, WANG-TSO, 王緖斌;翁妏謹;李妮鍾;胡務亮;范碧娟;李旺祚   +1 more
core   +1 more source

Reversible methamphetamine-induced cardiomyopathy mimicking arrhythmogenic right ventricular cardiomyopathy with ventricular tachycardia

, 2020
Among numerous etiologies of ventricular arrhythmias, arrhythmogenic right ventricular cardiomyopathy (ARVC) and methamphetamine-induced cardiomyopathy (MAC) are 2 of the rarer causes of ventricular arrhythmias.1 ARVC is a disease that is characterized ...
Yu, AS, Rowe, M, Martin, P, Dahiya, A
core   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Cardiomyopathy

, 2011
Cardiomyopathy includes a spectrum of conditions of various pathologies. The appropriate diagnostic tools should be used to achieve the diagnosis and plan the appropriate management.
Maged William (21133769)
core  

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

, 2020
Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (LVOT) obstruction.
Jensen, Morten K, Bondue, Antoine, Afshar, Kia, Hegde, Sheila SM, Oreziak, Artur, Bhattacharya, Mondira, Solomon, Scott D., Wheeler, Matthew T., Waldman, Cynthia Burstein, Ho, Carolyn Y, Sehnert, Amy J., Solomon, Scott D, Kubanek, Milos, Garcia-Pavia, Pablo, Sehnert, Amy AJ, Zhang, David, Brunner-La Rocca, Hans peter; id_orcid, Wheeler, Matthew MT, Lakdawala, Neal K., Masri, Ahmad, Li, Wanying, Wang, Andrew, Abraham, Theodore P, Edelberg, Jay JM, Edelberg, Jay M., Saberi, Sara, Abraham, Theodore P., Brunner-La Rocca, Hans peter, Barriales-Villa, Roberto, Jacoby, Daniel, Lakdawala, Neal NK, Gimeno-Blanes, Juan, Myers, Jonathan, Lester, Steven J., Hegde, Sheila M., Lester, Steven J, Owens, Anjali, Wojakowski, Wojciech, Jensen, Morten K., Ho, Carolyn Y., Olivotto, Iacopo   +40 more
core   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Heart disease in infants of diabetic mothers [PDF]

, 2000
Congenital anomalies occur more commonly in infants born to diabetic mothers, and cardiac defects predominate. Although respiratory problems are also frequently found in those infants, they need to be differentiated from cardiovascular problems that ...
Narchi, Hassib, Kulaylat, N.
core  

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Evidence of Declining Mortality Trends for Hypertrophic Cardiomyopathy in the United States and the Impact of the COVID‐19 Pandemic

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Dedicated hypertrophic cardiomyopathy (HCM) center cohorts have reported reductions in HCM‐related deaths, likely due to the introduction of contemporary treatments.
Ahmed Sayed, Barry J. Maron, Ethan J. Rowin, Martin S. Maron   +3 more
doaj   +1 more source