Cardiorenal Protection in Diabetic Kidney Disease [PDF]
Endocrinology and Metabolism, 2021 Over the last 5 years there have been many new developments in the management of diabetic kidney disease. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT2) inhibitors were initially used for glycemic control,
Jason F. Lee +4 more
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Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming [PDF]
EBioMedicine, 2022 Summary: Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed as a novel class of anti-hyperglycaemic drugs, have been shown to significantly improve metabolic indicators and protect the kidneys and heart of patients with or without ...
Yue-Ming Gao +5 more
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Emerging role of antidiabetic drugs in cardiorenal protection [PDF]
Frontiers in PharmacologyThe global prevalence of diabetes mellitus (DM) has led to widespread multi-system damage, especially in cardiovascular and renal functions, heightening morbidity and mortality.
Wen-Jia Fu +31 more
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The expanding role of SGLT2 inhibitors beyond glucose-lowering to cardiorenal protection [PDF]
Annals of Medicine, 2021 The kidney plays a major physiological role in glucose homeostasis but also contributes to the pathophysiology of type 2 diabetes (T2D), mediated by renal sodium glucose cotransporters (SGLTs).
Emily Brown +5 more
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Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors [PDF]
Biomolecules, 2022 Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and associated with an increased risk of morbidity and mortality, primarily from cardiovascular and renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is)
Francesca Romana Prandi +8 more
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Mechanisms of Cardiorenal Protection With SGLT2 Inhibitors in Patients With T2DM Based on Network Pharmacology [PDF]
Frontiers in Cardiovascular Medicine, 2022 PurposeSodium-glucose cotransporter 2 (SGLT2) inhibitors have cardiorenal protective effects regardless of whether they are combined with type 2 diabetes mellitus, but their specific pharmacological mechanisms remain undetermined.Materials and MethodsWe ...
Anzhu Wang +13 more
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Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection [PDF]
International Journal of Molecular Sciences, 2020 The development of sodium-glucose transporter 2 inhibitor (SGLT2i) broadens the therapeutic strategies in treating diabetes mellitus. By inhibiting sodium and glucose reabsorption from the proximal tubules, the improvement in insulin resistance and natriuresis improved the cardiovascular mortality in diabetes mellitus (DM) patients.
Yi-Chou Hou +2 more
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Aldosterone Synthase Inhibitors for Cardiorenal Protection: Ready for Prime Time?
Kidney & Blood Pressure ResearchBackground: Aldosterone is the principal mineralocorticoid hormone and the final effector of the renin-angiotensin-aldosterone system. This hormone is primarily synthesized by the CYP11B2 enzyme and produced by the adrenal zona glomerulosa ...
Alessio Mazzieri +5 more
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Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction [PDF]
Cardiology Research and Practice, 2020 Objective. Understanding the multifactorial changes involved in the kidney and heart after acute myocardial infarction (AMI) is prerequisite for further mechanisms and early intervention, especially autophagy changes.
Zhendong Feng +11 more
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Mechanisms for Cardiorenal Protection of SGLT-2 Inhibitors
Current Pharmaceutical Design, 2021 Despite optimal treatment of diabetic kidney disease (DKD) with adequate blood pressure control and agents blocking the renin-angiotensin-system (RAS), the residual cardiorenal risk of these patients remains substantially high. There is, therefore, an unmet need for additional therapies effective to retard the progression of DKD and improve ...
Panagiotis Georgianos +2 more
exaly +4 more sources