Results 111 to 120 of about 4,731,201 (386)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer [PDF]

, 2007
Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal ...
Andrew Stanley, Christopher C. McConkey, Claire Iveson, David J. Kerr, Giovannucci E, Janet A. Dunn, Joanne C. Stokes, Justine L. Smith, Michael J. Langman, Oshima M, Patrick Julier, Rachel S.J. Midgley, Ravi Duvvuri, Thun MJ   +13 more
core   +1 more source

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Cardiovascular Research, 2020
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic considerations for ...
T. Guzik, Saidi A Mohiddin, A. Dimarco, V. Patel, K. Savvatis, F. Marelli-Berg, M. Madhur, M. Tomaszewski, P. Maffia, F. D’Acquisto, S. Nicklin, A. Marian, R. Nosalski, E. Murray, B. Guzik, C. Berry, R. Touyz, R. Kreutz, Daowen Wang, D. Bhella, Orlando Sagliocco, F. Crea, E. Thomson, I. McInnes   +23 more
semanticscholar   +1 more source

Genetic diversity and population structure of the Taigan dog breed

FEBS Open Bio, EarlyView.
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova, Anastassiya Perfilyeva, Мamura Begmanova, Assel Zhaxylykova, Arailym Yerzhan, Kanagat Yergali, Almazbek Akunov, Marat Munarbek uulu, Anna Khamchukova, Almira Amirgaliyeva, Yelena Kuzovleva   +10 more
wiley   +1 more source

A Pharmacological Examination of the Cardiovascular Effects of Malayan Krait (Bungarus candidus) Venoms

Toxins, 2017
Cardiovascular effects (e.g., tachycardia, hypo- and/or hypertension) are often clinical outcomes of snake envenoming. Malayan krait (Bungarus candidus) envenoming has been reported to cause cardiovascular effects that may be related to abnormalities in ...
Janeyuth Chaisakul, Muhamad Rusdi Ahmad Rusmili, Wayne C. Hodgson, Panadda Hatthachote, Kijja Suwan, Anjaree Inchan, Lawan Chanhome, Iekhsan Othman, Krongkarn Chootip   +8 more
doaj   +1 more source

Cardiovascular diseases, risk factors and barriers in their prevention in Croatia [Kardiovaskularne bolesti, rizični faktori i zapreke za prevenciju u Hrvatskoj] [PDF]

, 2009
Cardiovascular diseases are the leading cause of death in Croatia, with significant regional differences. Despite high mortality rates, high prevalence of various cardiovascular risk factors and well organized public health network, comprehensive system ...
Andrić, Adriana, Džakula, Aleksandar, Juriša, Adriana, Polašek, Ozren, Radaković, Nikolina, Todorović, Goran, Šogorić, Selma   +6 more
core  

Comparing the effectiveness of two cardiovascular prevention programmes for highly educated professionals in general practice : a randomised clinical trial [PDF]

, 2013
Background: Cardiovascular disease is a major cause of mortality and morbidity and its prevalence is set to increase. While the benefits of medical and lifestyle interventions are established, the effectiveness of interventions which seek to improve the ...
Claes, Neree, Clays, Els, De Bourdeaudhuij, Ilse, Jacobs, Nele, Schrooten, Ward   +4 more
core   +2 more sources

UR‐cycleGAN: Denoising full‐body low‐dose PET images using cycle‐consistent Generative Adversarial Networks

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to develop a CycleGAN based denoising model to enhance the quality of low‐dose PET (LDPET) images, making them as close as possible to standard‐dose PET (SDPET) images. Methods Using a Philips Vereos PET/CT system, whole‐body PET images of fluorine‐18 fluorodeoxyglucose (18F‐FDG) were acquired from 37 patients to ...
Yang Liu, ZhiWu Sun, HaoJia Liu
wiley   +1 more source

Cardiovascular autonomic neuropathy among non- insulin dependent diabetics patients [PDF]

, 2014
Background and Objective: Cardiovascular autonomic neuropathy (CAN) is the most common and important type of diabetic autonomic neuropathy. Silent myocardial infarction, respiratory failure and increased mortality are the outcomes of CAN.
Bazrafshan, H.R., Hosseini, S.M., Maleki, A.R.   +2 more
core  

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients [PDF]

, 2017
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development
Alessandri, Cristiano, Ciciarello, Francesco Luigi, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Miranda, Francesca, Pecani, Arbi, Spinelli, FRANCESCA ROMANA, Valesini, Guido   +8 more
core   +1 more source