Results 291 to 300 of about 3,873,787 (338)

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among patients with hypertension in the US. [PDF]

BMC Cardiovasc Disord
Hu N, Feng Y, He L.
europepmc   +1 more source

Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications

Advanced Materials, EarlyView.
Vasculature is indispensable for tissue viability in regenerative medicine. The sacrificial biofabrication enables precise fabrication of vascular channels by using temporary templates that are subsequently removed. This review defines the concept and delves into sacrificial materials, surrounding materials, fabrication technologies, and biomedical ...
Jiezhong Shi, Chunyao Wang, Xuan Mei, Ben Zhang, Junxi Wu, Rylie A. Green, Yu Shrike Zhang, Wenmiao Shu   +7 more
wiley   +1 more source

The polyunsaturated-to-monounsaturated fatty acid ratio and cardiovascular risk prediction: a prospective cohort study of 183,237 adults. [PDF]

Lipids Health Dis
Sun M, Jiang D, Long X, Chen X.
europepmc   +1 more source

Rapid Glass‐Substrate Digital Light 3D Printing Enables Anatomically Accurate Stroke Patient‐Specific Carotid Artery‐on‐Chips for Personalized Thrombosis Investigation

Advanced Materials, EarlyView.
A rapid glass‐substrate 3D microfabrication method creates anatomically accurate carotid artery‐on‐a‐chip models from stroke patient scans in 2 h. These miniaturized devices replicate patient‐specific blood vessel geometry and flow patterns, enabling real‐time imaging of clot formation under controlled injury.
Yunduo Charles Zhao, Zihao Wang, Arian Nasser, Allan Sun, Zhao Wang, Yingqi Zhang, Jianfang Ren, Haimei Zhao, Nicole Alexis Yap, Yinyan Wang, Zhiyong Li, Ken S Butcher, Freda Passam, Timothy Ang, Lining Arnold Ju   +14 more
wiley   +1 more source

Optimization of Clinical Trial Design and Decision-Making for Heart Failure with Preserved Ejection Fraction (HFpEF): A Meta-Analysis Based on a Placebo Response Model. [PDF]

Cardiovasc Ther
Chen X, Yang J, Xu L, Yin F, Huang J, Lv Y, Zheng Q, Li L.   +7 more
europepmc   +1 more source

Physical Intelligence in Small‐Scale Robots and Machines

Advanced Materials, EarlyView.
“Physical intelligence” (PI) empowers biological organisms and artificial machines, especially at the small scales, to perceive, adapt, and even reshape their complex, dynamic, and unstructured operation environments. This review summarizes recent milestones and future directions of PI in small‐scale robots and machines.
Huyue Chen, Metin Sitti
wiley   +1 more source

The combined prognostic effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with cardiovascular-kidney-metabolic syndrome stages 0-3. [PDF]

BMC Cardiovasc Disord
Wang K, Wang W, Niu J, Liu Y, Wang Z, Wang Z, Han H, Sun Y, Liu X, Ge H.   +9 more
europepmc   +1 more source

Cardiovascular effects of hypertonic lactate solutions: acid-base or metabolic cause, or both? Authors' reply. [PDF]

Crit Care
Berg-Hansen K, Pedersen MGB, Gopalasingam N, Hørsdal OK, Møller N, Wiggers H, Nielsen R.   +6 more
europepmc   +1 more source

A gender-integrated biopsychosocial model to understand cardiovascular risk in women working under environmental hazards: the case of chronic intermittent hypoxia. [PDF]

Front Public Health
Lang M, Cazzuffi C, Viscor G, Soto-Sánchez J.   +3 more
europepmc   +1 more source