Results 41 to 50 of about 462,488 (300)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The CANVAS Program: implications of canagliflozin on reducing cardiovascular risk in patients with type 2 diabetes mellitus

Cardiovascular Diabetology, 2019
Canagliflozin is a sodium glucose co-transporter 2 (SGLT2) inhibitor that reduces blood glucose, as well as blood pressure, body weight, and albuminuria in patients with type 2 diabetes mellitus (T2DM).
Salvatore Carbone, Dave L. Dixon
doaj   +1 more source

Uncontrolled and apparent treatment resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds

BMC Cardiovascular Disorders, 2020
Background Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the ...
Jakob Petersen, Sofia Malyutina, Andrey Ryabikov, Anna Kontsevaya, Alexander V. Kudryavtsev, Anne Elise Eggen, Martin McKee, Sarah Cook, Laila A. Hopstock, Henrik Schirmer, David A. Leon   +10 more
doaj   +1 more source

Cardiovascular Management in Pregnancy [PDF]

Circulation, 2015
Thrombotic complications of pregnancy are a major cause of morbidity and mortality to the mother and fetus. Pulmonary embolism is a leading cause of maternal death and accounts for 10.3% of all maternal deaths in the United States.1,2 Overall, pregnancy increases the risk of venous thromboembolism (VTE) 5-fold, with an additional increase in risk in ...
Christina D, Yarrington, Anne Marie, Valente, Katherine E, Economy   +2 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Cardiovascular safety of non-insulin pharmacotherapy for type 2 diabetes

, 2017
Patients with type 2 diabetes mellitus have a twofold increased risk of cardiovascular mortality compared with non-diabetic individuals. There is a growing awareness that glycemic efficacy of anti-diabetic drugs does not necessarily translate to ...
Rajaratnam, Rohan (R14440), Xu, J ; https://orcid.org/, Rajaratnam, R ; https://orcid.org/, Xu, James   +3 more
core   +1 more source

Cardiotoxicity of Non-Anthracycline Cancer Chemotherapy Agents

, 2022
Throughout the last decades, newly developed chemotherapeutic agents and immunotherapies that target signaling pathways have provided patients with better prognoses, improved their quality of life and increased survival rates, thus converting cancer to a
Nikolaos Panagiotou, Alexandros Briasoulis, Ioannis Paraskevaidis, Alexandros Sianis, Argyrios Ntalianis, Angeliki Chasouraki, Christos Kourek   +6 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Overview of the RGD-Based PET Agents Use in Patients With Cardiovascular Diseases: A Systematic Review

Frontiers in Medicine, 2022
Studies using arginine–glycine–aspartate (RGD)-PET agents in cardiovascular diseases have been recently published. The aim of this systematic review was to perform an updated, evidence-based summary about the role of RGD-based PET agents in patients with
Matthieu Dietz, Matthieu Dietz, Christel H. Kamani, Christel H. Kamani, Vincent Dunet, Vincent Dunet, Stephane Fournier, Stephane Fournier, Vladimir Rubimbura, Nathalie Testart Dardel, Ana Schaefer, Mario Jreige, Sarah Boughdad, Marie Nicod Lalonde, Marie Nicod Lalonde, Niklaus Schaefer, Niklaus Schaefer, Nathan Mewton, Nathan Mewton, Nathan Mewton, John O. Prior, John O. Prior, Giorgio Treglia, Giorgio Treglia, Giorgio Treglia, Giorgio Treglia   +25 more
doaj   +1 more source

European cardiovascular magnetic resonance (EuroCMR) registry - multi national results from 57 centers in 15 countries [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Monney, P., Jürg Schwitter, Nothnagel, D., Monney, Pierre, Christina C Deluigi, Nagel, E, Georg Sabin, Steen, H., Günter Pilz, Anja Wagner, Nagel, Eike, van Rossum, A, Bruder, Oliver, Deluigi, Christina C, Lombardi, M, Simon Greulich, Wagner, A., van Rossum, Albert, Dill, T, Dill, T., Herbert Frank, Oliver Bruder, Prasad, Sanjay, Frank, Herbert, Sabin, G, Nothnagel, D, Albert van Rossum, Frank, H., Petersen, S., Prasad, S, Petersen, Steffen, Nagel, E., Steffen Petersen, Heiko Mahrholdt, Detlev Nothnagel, Alessandro Cagnolo, Mahrholdt, Heiko, Wagner, Anja, Deluigi, CC, Cagnolo, A, Schneider, S, van Rossum, A.C., van Rossum, A., Petersen, S, Pilz, G., Schneider, S., Pilz, G, Monney, P, Dill, Thorsten, Greulich, S., Sabin, Georg, Cagnolo, Alessandro, Nothnagel, Detlev, Steen, Henning, Massimo Lombardi, Lombardi, M., Schwitter, J., Greulich, Simon, Greulich, S, Steffen Schneider, Thorsten Dill, Sabin, G., Wagner, A, Sanjay Prasad, Prasad, S., Bruder, O, Cagnolo, A., Steen, H, Mahrholdt, H, Julia Schumm, Henning Steen, Schumm, Julia, Bruder, O., Deluigi, C.C., Schwitter, J, Mahrholdt, H., Schneider, Steffen, Pierre Monney, Lombardi, Massimo, Schwitter, Jürg, Schumm, J., Schumm, J, Frank, H, Pilz, Günter, Eike Nagel   +84 more
core   +1 more source