Results 41 to 50 of about 523,804 (280)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Cardiovascular complications of COVID-19

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. The problem of COVID-19 today is the most unresolved worldwide. Scientists and doctors all over the world are trying to study features of pathogenesis this disease to find the most effective treatment methods.
N.V. Bila, M.S. Brynza, N.V. Tytarenko
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action

Antioxidants, 2022
Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High morbidity and mortality caused by DM are closely linked to its complications in multiple organs/tissues, including cardiovascular complications, diabetic nephropathy ...
Meiming Su, Wenqi Zhao, Suowen Xu, Jianping Weng   +3 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cushing’s disease – cardiovascular and metabolic complications

Pediatria i Medycyna Rodzinna, 2019
Cushing’s disease is excess cortisol level due to increased adrenocorticotropin secretion from pituitary adenoma. Incidence rate is 2–3 cases per year and the prevalence is 40 per 1 million people.
Marta Izabela Mazur, Grzegorz Zieliński, Joanna Witek, Katarzyna Szamotulska, Przemysław Witek   +4 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Outcomes of Pregnancy in Patients With Prior Right Ventricular Outflow Interventions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The purpose of this study was to compare the incidence of pregnancy‐related adverse outcomes (PRAO) between patients with versus without hemodynamically significant right ventricle outflow tract (RVOT).
Alexander C. Egbe, Majd El‐Harasis, William R. Miranda, Naser M. Ammash, Carl H. Rose, Ayotola Fatola, Srikanth Kothapalli, Mohamed Farouk Abdelsamid, Heidi M. Connolly   +8 more
doaj   +1 more source

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes [PDF]

, 2023
Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi, Hoi Man Cheung, Alex C.W. Ng, Heung Man Lee, Eric S. H. Lau, Baoqi Fan, Guozhi Jiang, Alice P.S. Kong, Risa Ozaki, Elaine Chow, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Leung, Elaine Cheung, Man Wo Tsang, Grace Kam, Ip Tim Lau, June K.Y. Li, Ming Wai Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Xiaodan Fan, Ting‐Fung Chan, Kevin Y.L. Yip, Si Lok, Weichuan Yu, Stephen Kwok‐Wing Tsui, Hui Y. Lan, Cheuk‐Chun Szeto, Nelson L.S. Tang, Brian Tomlinson, Yü Huang, Alicia J. Jenkins, Anthony Keech, Wing-yee So, Juliana C.N. Chan, Ronald C.W., Ronald C.W., Juliana C.N. Chan, Risa Ozaki, Andrea O. Y. Luk, Wing-yee So, Ka-Fai Lee, Shing‐Chung Siu, Grace Hui, Chiu-Chi Tsang, Kam-Piu Lau, Jenny Leung, Man-Wo Tsang, Grace Kam, Elaine Cheung, Ip Tim Lau, June K.Y. Li, Ming Wai Yeung, Jo Jo Kwan, Samuel Fung, Stanley Lo, Emmy Lau, Yuk‐Lun Cheng, Stephen Kwok‐Wing Tsui, Yü Huang, Hui Y. Lan, Weichuan Yu, Brian Tomlinson, Si Lok, Ting‐Fung Chan, Kevin Y.L. Yip, Cheuk‐Chun Szeto, Xiaodan Fan, Nelson L.S. Tang, Xiao Yu Tian, Claudia H.T. Tam, Guozhi Jiang, Mai Shi, Baoqi Fan, Fei Xie, Sen Zhang, Yu Pu, Meng Wang, Heung Man Lee, Cadmon K.P. Lim, Fangying Xie, Alex C.W. Ng, Grace P.Y. Cheung, Alice P.S. Kong, Elaine Chow, Ming Wai Yeung, Chun‐Chung Chow, Kitty Kit-Ting Cheung, Rebecca Y.M. Wong, Hon‐Cheong So   +99 more
openalex   +1 more source