Results 161 to 170 of about 797,541 (308)

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

GDF-15 at admission predicts cardiovascular death, heart failure, and bleeding outcomes in patients with CAD. [PDF]

ESC Heart Fail, 2023
Wang J, Zhang T, Xu F, Gao W, Chen M, Zhu H, Xu J, Yin X, Pang J, Zhang S, Wei M, Chen J, Liu Y, Yu X, Chew DP, Chen Y.   +15 more
europepmc   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

The influence of atrial high-rate episodes on stroke and cardiovascular death: an update. [PDF]

Europace, 2023
Toennis T, Bertaglia E, Brandes A, Dichtl W, Fluschnik N, de Groot JR, Marijon E, Mont L, Lundqvist CB, Cabanelas N, Dan GA, Lubinski A, Merkely B, Rajappan K, Sarkozy A, Velchev V, Wichterle D, Kirchhof P.   +17 more
europepmc   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Trajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study. [PDF]

BMC Med, 2023
Kimenai DM, Anand A, de Bakker M, Shipley M, Fujisawa T, Lyngbakken MN, Hveem K, Omland T, Valencia-Hernández CA, Lindbohm JV, Kivimaki M, Singh-Manoux A, Strachan FE, Shah ASV, Kardys I, Boersma E, Brunner EJ, Mills NL.   +17 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study. [PDF]

J Am Heart Assoc
Hong L, Shi W, Song J, Wan S, Huo Z, Zhang Y, Liu Q, Wang F, Xiong Y, Shi D, Chen P, Chen W, Wang B.   +12 more
europepmc   +1 more source

A deep learning-based electrocardiogram risk score for long term cardiovascular death and disease. [PDF]

NPJ Digit Med, 2023
Hughes JW, Tooley J, Torres Soto J, Ostropolets A, Poterucha T, Christensen MK, Yuan N, Ehlert B, Kaur D, Kang G, Rogers A, Narayan S, Elias P, Ouyang D, Ashley E, Zou J, Perez MV.   +16 more
europepmc   +1 more source