Results 61 to 70 of about 3,668,940 (297)

Hypoglycemia, Cardiovascular Outcomes, and Death: The LEADER Experience [PDF]

Diabetes Care, 2018
OBJECTIVE In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) cardiovascular (CV) outcomes trial (NCT01179048), liraglutide significantly reduced the risk of CV events (by 13%) and hypoglycemia versus placebo.
Bernard Zinman, Steven P. Marso, Erik Christiansen, Salvatore Calanna, Søren Rasmussen, John B. Buse   +5 more
openaire   +2 more sources

N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS [PDF]

, 2013
<b>Aims:</b>To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort.
Ford, I., Welsh, P., Doolin, O., Packard, C., Cobbe, S., Macfarlane, P., Gudnason, V., Di Angelantonio, E., Sattar, N., Willeit, P.   +9 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients

Therapeutics and Clinical Risk Management, 2021
Ling-Cang Xu,1,2 Fang-Fang Zhou,1,2 Meng Li,1,2 Zhi-Wei Dai,1,2 Ke-Dan Cai,1,2 Bei-Xia Zhu,1,2 Qun Luo1,2 1Department of Nephrology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang Province, 315010, People’s Republic of ...
Xu LC, Zhou FF, Li M, Dai ZW, Cai KD, Zhu BX, Luo Q   +6 more
doaj  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

A narrative review of inherited arrhythmogenic syndromes in young population: role of genetic diagnosis in exercise recommendations

BMJ Open Sport & Exercise Medicine
Sudden cardiac death is a rare but socially devastating event, especially if occurs in young people. Usually, this unexpected lethal event occurs during or just after exercise. One of the leading causes of sudden cardiac death is inherited arrhythmogenic
Elena Arbelo, Gonzalo Grazioli, Carles Díez-López, Oscar Campuzano, Georgia Sarquella-Brugada, Sergi Cesar, Estefanía Martínez-Barrios, Rocío Toro, José Cruzalegui, Andrea Greco, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Norma Balderrábano   +13 more
doaj   +1 more source

Cardiovascular and Other Competing Causes of Death in Male Breast Cancer Patients: A Population-Based Epidemiologic Study

Clinical Interventions in Aging, 2021
Hanbin Zhang,1 Wenrui Lin,2 Dongting Chen,1 Kenie Wang,3 Wei Tu,4 Huiwen Lin,4 Kun Li,4 Shangzhu Ye,5 Tianwang Guan,6 Yuerong Chen4 1Department of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, People’s ...
Zhang H, Lin W, Chen D, Wang K, Tu W, Lin H, Li K, Ye S, Guan T, Chen Y   +9 more
doaj  

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Competing risk nomogram for predicting cancer-specific survival in patients with primary bone diffuse large B-cell lymphoma: a SEER-based retrospective study

Frontiers in Medicine
BackgroundCardiovascular death (CVD) represents a significant determinant affecting the long-term survival outcomes of cancer patients, independent of primary tumor effects.
Rongbin Shen, Sichun Xiang, Jianyou Gu, Yu Zhang, Lili Qian, Jianping Shen, Qing Guo, Shana Chen, Chenyang Ma, Jingjing Xiang   +9 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source