Results 141 to 150 of about 2,726,604 (341)

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Hemoglobin glycation index and cardiovascular outcomes in patients with diabetes and coronary artery disease: insights from a large cohort study

Nutrition & Diabetes
Background/objectives The hemoglobin glycation index (HGI) has been demonstrated to serve as a substitute for the individual bias in glycosylated hemoglobin A1c (HbA1c).
Zhangyu Lin, Jining He, Sheng Yuan, Chenxi Song, Xiaohui Bian, Min Yang, Kefei Dou   +6 more
doaj   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Aches and Pains: The challenge of ASCVD prevention in patients with hyperlipidemia and statin-intolerance

American Journal of Preventive Cardiology, 2020
David M. Harmon, MD, Tyler Schmidt, MD, Nadia Akhiyat, MD, MS, Erica Kludtke, RN, Stephen L. Kopecky, MD   +4 more
doaj   +1 more source

Beyond the Echo: Is Comprehensive Vascular Exploration Valuable in Cases of Non-Syndromic Thoracic Aortic Aneurysms or Bicuspid Aortic Valve?

Journal of Cardiovascular Development and Disease
Bicuspid aortic valve (BAV) and thoracic aortic aneurysms and dissections (TAAD) are recognized in syndromic connective tissue diseases (CTD), but most cases occur sporadically.
Austin Saugstad, Srekar Ravi, George Bcharah, Christine E. Firth, Hend Bcharah, Hussein Abdul Nabi, Hoang Nhat Pham, Ramzi Ibrahim, Sant J. Kumar, Mahmoud Abdelnabi, Linnea M. Baudhuin, Yuxiang Wang, Mayowa A. Osundiji, Fadi Shamoun   +13 more
doaj   +1 more source

Hyperuricemia is associated with cardiovascular diseases clustering among very elderly women - a community based study in Chengdu, China

Scientific Reports, 2017
Cardiovascular epidemiological features among very elderly Chinese are still uncertain. This study aimed to describe the distribution of cardiovascular diseases and sex difference, and investigate potential risk factors for diseases clustering among very
Gang Huang, Jun-bo Xu, Ting-jie Zhang, Xiao-li Nie, Qiu Li, Ya liu, Yan Lv, Rui-lian Wen, Lei Yang, Bao-yu Zhao   +9 more
doaj   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Dramatic LDL-Cholesterol elevation with Ketogenic Diet: A Case Series

American Journal of Preventive Cardiology, 2020
David Harmon, Sean Regner, MD, Khansa Osman, MD, Cimmie Shahan, MD, Babikir Kheiri, MD, Madhavi Kadiyala, MD, George Sokos, DO, Partho P. Sengupta, MD, Erin D. Michos, MD MHS, Christopher Bianco, DO   +9 more
doaj   +1 more source

Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration

Nature Communications
Promoting endogenous cardiomyocyte proliferation is a promising strategy for cardiac repair. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration.
Dongcheng Cai, Chungeng Liu, Haotong Li, Chiyin Wang, Lina Bai, Jie Feng, Miaoqing Hu, Hao Wang, Shen Song, Yifan Xie, Ziwei Chen, Jiajun Zhong, Hong Lian, Zhiwei Yang, Yuhui Zhang, Yu Nie   +15 more
doaj   +1 more source