Results 251 to 260 of about 10,789,024 (363)

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

Epidemiology of Cardiovascular Disease in India

, 1962
S Padmavati
openalex   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

A Systematic Bibliometric Analysis of Cardiovascular Disease Risk in Obesity (2014-2024). [PDF]

J Multidiscip Healthc
Yang H, Zhang T, Wang D, Loi E, Geng Q, Wu B, Wang X, Cai R.   +7 more
europepmc   +1 more source

Non‐Invasive Diagnosis of Chronic Myocardial Infarction via Composite In‐Silico‐Human Data Learning

Advanced Science, EarlyView.
This study presents a non‐invasive machine learning model to identify infarct regions in the left ventricle using cardiac strain data. By combining rodent‐based simulated data with limited human data, the model achieves high accuracy in predicting infarct size and location without the need for gadolinium contrast agents, offering a promising ...
Rana Raza Mehdi, Nikhil Kadivar, Tanmay Mukherjee, Emilio A. Mendiola, Akila Bersali, Dipan J. Shah, George Karniadakis, Reza Avazmohammadi   +7 more
wiley   +1 more source

Exploring the potential of honokiol as a treatment for cardiovascular disease (Review). [PDF]

Biomed Rep
Zeng Y, Li Z, Lin X.
europepmc   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Cardiovascular disease and radiopharmaceutical therapies- an underestimated risk? [PDF]

Eur J Nucl Med Mol Imaging
Lassmann M, Eberlein U, Verburg FA.
europepmc   +1 more source

The Prevalence of Spontaneously Occuring Cardiovascular Disease in Dogs

, 1961
D. K. Detweiler, D. F. Patterson, K Hubben, Robert P. Botts   +3 more
openalex   +2 more sources

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

New England Journal of Medicine, 2017
J. Eikelboom, S. Connolly, J. Bosch, G. Dagenais, R. Hart, O. Shestakovska, R. Diaz, M. Alings, E. Lonn, Sonia S Anand, P. Widimsky, M. Hori, Á. Avezum, L. Piegas, K. Branch, J. Probstfield, Deepak L. Bhatt, Jun Zhu, Yan Liang, A. Maggioni, P. López-Jaramillo, M. O’Donnell, Ajay Kakkar, K. Fox, A. Parkhomenko, G. Ertl, S. Störk, M. Keltai, L. Rydén, N. Pogosova, A. Dans, F. Lanas, P. Commerford, C. Torp-Pedersen, T. Guzik, P. Verhamme, D. Vinereanu, Jae‐Hyung Kim, A. Tonkin, B. Lewis, C. Félix, K. Yusoff, G. Steg, K. Metsarinne, N. C. Bruns, F. Misselwitz, E. Chen, D. Leong, S. Yusuf   +48 more
semanticscholar   +1 more source