Results 251 to 260 of about 2,636,084 (314)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Editorial: Immunity, atherosclerosis, and cardiovascular disease: an interdisciplinary approach to cardiometabolic health. [PDF]

Front Cardiovasc Med
Chelvanambi S, Bernhagen J, Fredman G, Labarrere CA, Winkels H, Aikawa M.   +5 more
europepmc   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics. [PDF]

Diabetes Metab Res Rev
Anagnostopoulou L, Ktenopoulos N, Apostolos A, Fragoulis C, Vlachakis P, Karakasis P, Sagris M, Milaras N, Drakopoulou M, Synetos A, Kyriazis I, Ioannidis I, Tsioufis C, Toutouzas K.   +13 more
europepmc   +1 more source

Sex Differences in Cardiovascular Disease Outcomes After Traumatic Brain Injury. [PDF]

JACC Adv
Balke JE, Stewart IJ, Amuan ME, Howard JT, Brown JE, Kennedy E, Haigney M, Pugh MJ.   +7 more
europepmc   +1 more source

Lung capacity is a determinant of cardiovascular disease and myocardial infarction. [PDF]

Respir Res
Knox-Brown B, Sibomana JP, Sylvester KP, Amaral AFS.   +3 more
europepmc   +1 more source