Results 121 to 130 of about 11,679,175 (389)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +2 more sources

Studying biological science does not lead to adoption of a healthy lifestyle [PDF]

, 2020
Aims: The lifestyle and physical activity (PA) habits of young people play a key role in the prevention of cardiovascular and metabolic diseases at older ages.
Bhatti, Sunbal N., Leake, David, Leidi, Alessandro, Li, Jian-mei   +3 more
core   +1 more source

Bioabsorbable bypass grafts biofunctionalised with RGD have enhanced biophysical properties and endothelialisation tested in vivo

Frontiers in Pharmacology, 2016
Small diameter arterial bypass grafts are considered as unmet clinical need since the current grafts have poor patency of 25% within 5 years. We have developed a 3D scaffold manufactured from natural and synthetic biodegradable polymers, poly(3 ...
Larisa V Antonova, Anton G. Kutikhin, Alexander Marcus Seifalian, Alexander Marcus Seifalian, Victoria V Sevostyanova, Evgeniya O Krivkina, Andrey V Mironov, Andrey Yu Burago, Elena A Velikanova, Vera G Matveeva, Tatiana V Glushkova, Evgeniya A Sergeeva, Georgiy Yu Vasyukov, Yuliya A Kudryavtseva, Olga L Barbarash, Leonid S Barbarash   +15 more
doaj   +1 more source

Six-months success of radiofrequency ablation in cardiac arrhythmias treatment: Experience of our centre [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Numerous trials have shown a high success of radiofrequency ablation (RFA) in the treatment of the patients with cardiac arrhythmias. We aimed to examine the RFA initial success in treatment of different cardiac arrhythmias and the RFA ...
Jurčević-Mudrić Ružica, Angelkov Lazar, Tomović Milosav, Kojić Dejan, Milojević Predrag   +4 more
doaj   +1 more source

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

Nutrients, 2019
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic mechanisms and increased oxidative stress has been viewed as one of the potential common etiologies. A fine balance between the presence of reactive oxygen species (ROS)
T. Senoner, W. Dichtl
semanticscholar   +1 more source

COVID-19 and cardiovascular diseases

Journal of Molecular Cell Biology, 2020
The coronavirus disease 2019 (COVID-19) remains a global public health emergency. Despite being caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), besides the lung, this infectious disease also has severe implications in the ...
Fan Liu, Feng Liu, Lu Wang
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast Subpopulations

Cardiology Research and Practice
Background. Cardiomyopathy encompasses a broad spectrum of diseases affecting myocardial tissue, characterized clinically by abnormalities in cardiac structure, heart failure, and/or arrhythmias.
Wenyang Nie, Zhijie Zhao, Yuhang Liu, Youcao Wang, Jingwen Zhang, Ying Hu, Yang Liu, Yong Wang, Zhen Wang   +8 more
doaj   +1 more source

Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases

Frontiers in Cell and Developmental Biology, 2020
The endoplasmic reticulum (ER) and mitochondria are physically connected to form dedicated structural domains known as mitochondria-associated ER membranes (MAMs), which participate in fundamental biological processes, including lipid and calcium (Ca2 ...
Peng Gao, Zhencheng Yan, Zhiming Zhu
semanticscholar   +1 more source