Results 241 to 250 of about 2,115,525 (309)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Exploring Galectin‑3 as an Emerging Frontier in Biomarker Research for Clinical Trials Approaching Cardiovascular Diseases. [PDF]

ACS Pharmacol Transl Sci
Perpétuo L.
europepmc   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

The Relation of Corneal Arcus With Cardiovascular Diseases: A Systematic Review. [PDF]

Cureus
Bonajmah H, Aljassar F, Bulbanat A, Almutairi R.   +3 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Prevalence and Risk Factors of Readmission Among Patients with Cardiovascular Diseases in Africa: A Systematic Review. [PDF]

J Epidemiol Glob Health
Nimo FA, Odoom E, Gyamfi-Samakome A, Koranteng HK, Duah M, Asore MA, Amoadu M, Enyan NIE.   +7 more
europepmc   +1 more source

Cellular senescence and cell therapy in cardiovascular diseases. [PDF]

Stem Cell Res Ther
Chang D, Wang J, Zhu S, Shentu Y, Wang Y, Zhu P, Ono M.   +6 more
europepmc   +1 more source

Association between social activities and cardiovascular diseases: evidence from the CHARLS database. [PDF]

BMC Public Health
Tao H, Dong L, Lou H.
europepmc   +1 more source

Ferroptosis: The Pivotal Link in Cardiovascular Diseases Pathogenesis and Therapy. [PDF]

Int J Gen Med
Guo S, Liu J, Hua J, Ding L, Chen Q.
europepmc   +1 more source