Results 61 to 70 of about 1,370,177 (306)

History of cardiovascular events and cardiovascular risk factors among patients initiating strontium ranelate for treatment of osteoporosis

International Journal of Women's Health, 2015
Jingbo Yu,1 Jackson Tang,2 Zhiyi Li,2 Shiva Sajjan,1 Christopher O’Regan,3 Ankita Modi,1 Vasilisa Sazonov11Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA; 2Asclepius Analytics Ltd., Wanchai,
Yu J, Tang J, Li Z, Sajjan S, O'Regan C, Modi A, Sazonov V   +6 more
doaj  

Long-term chronic lymphocytic leukemia survivors’ quality of life

Zaporožskij Medicinskij Žurnal, 2014
Aim: A comparative study of the long-term chronic lymphocytic leukemia survivors’ quality of life. Methods and results. One hundred three cumulative clinical events occurred in 45 patients (40,2%).
B. B. Samura
doaj   +1 more source

Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]

, 2005
Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen, Heeschen C, James SK, Khaliq A, Luttun A, Mak KH   +5 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț, Istrătoaie, Octavian, Moise, Cristiana G, Mustafa, Edme R, Rogoveanu, Ion, Tudorașcu, Diana R, TÂRTEA, Georgică C   +6 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events

JACC: Advances
Background: Observational data have suggested that patients with moderate to severe ischemia benefit from revascularization. However, this was not confirmed in a large, randomized trial. Objectives: Using a contemporary, multicenter registry, the authors
Robert JH. Miller, MD, Bryan Bednarski, MSc, Yujie Cui, MSc, Vinicius Calsavara, PhD, Krishna Patel, MD, Alan Rozanski, MD, Joanna X. Liang, MPH, Valerie Builoff, BSc, Wanda Acampa, MD, Timothy M. Bateman, MD, Marcelo Di Carli, MD, Sharmila Dorbala, MD, MPH, Andrew J. Einstein, MD, PhD, Matthews B. Fish, MD, M. Timothy Hauser, MD, Philipp A. Kaufmann, MD, Edward J. Miller, MD, PhD, Terrence D. Ruddy, MD, Tali Sharir, MD, Albert J. Sinusas, MD, Damini Dey, PhD, Daniel S. Berman, MD, Piotr J. Slomka, PhD   +22 more
doaj   +1 more source

Impact of Discrepancies in General and Abdominal Obesity on Major Adverse Cardiac Events

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Body mass index and waist circumference (WC) are commonly used metrics that reflect general obesity and abdominal obesity. However, the impact of general and abdominal obesity discrepancies on the risk for major adverse cardiac events (MACE ...
Daein Choi, Seulggie Choi, Joung Sik Son, Sang Woo Oh, Sang Min Park   +4 more
doaj   +1 more source

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]

, 2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan, Aaron Isaacs, Abbas Dehghan, AD Johnson, AD Johnson, Afshin Parsa, Alan R Shuldiner, Albert Hofman, Albert V Smith, AM Bennet, Andre Uitterlinden, Andreas Ziegler, Angelo Scuteri, Anne B Newman, Arne Schillert, Ben Oostra, BM Psaty, Bolli Thorsson, Braxton D Mitchell, Bruce M Psaty, C Meisinger, C Sabatti, Caroline Hayward, Caroline S Fox, Charles C White, Christa Meisinger, Christie Ballantyne, Christopher J O'Donnell, Cornelia van Duijn, CS Fox, D Lloyd-Jones, D Wang, Daniel H O'Leary, David J Couper, DI Chasman, DI Chasman, E Falk, EB Mathiesen, Edward G Lakatta, Eran Halperin, Eric Boerwinkle, Eva-Maria Stoegerer, Fernando Rivadeneira, Florian Ernst, Georg Homuth, Gerardo Heiss, Gianluca Usala, Gonçalo R Abecasis, Gudny Eiriksdottir, H Erich Wichmann, H Schunkert, H Yasuda, Helena Schmidt, Henry Völzke, Hugh S Markus, Jacqueline Witteman, James F Wilson, Jan Lüdemann, Jennifer E Huffman, Jens Baumert, Jerome I Rotter, JH Stein, Joachim Thiery, Jochen Seissler, Jorma Viikari, Joseph F Polak, Joshua C Bis, K Stark, K Yuan, Kari North, Katja E Petrovic, Kenneth Rice, Kent Taylor, L Adrienne Cupples, L Paternoster, Leena Peltonen, Lenore J Launer, M Kolz, M Oguri, Manuela Uda, Marco Orru, Marcus Dörr, Maryam Kavousi, Matthias Sitzer, Mika Kähönen, Muredach P Reilly, MW Lorenz, N Soranzo, Nora Franceschini, Norman Klopp, Olli Raitakari, P Greenland, Philip A Wolf, Philipp S Wild, R Nakov, R Ross, Ralph B D'Agostino, Ravi Kumar Chilukoti, Reinhold Schmidt, Renate B Schnabel, S Kathiresan, S Kathiresan, Sekar Kathiresan, Serena Sanna, Serkalem Demissie, SH Johnsen, Stefan Blankenberg, Steve Bevan, Susan R Heckbert, T Rahman, TA Manolio, Tamara B Harris, Tanja Zeller, Terho Lehtimäki, Thomas Illig, Thomas Münzel, Thor Aspelund, Ulf Schminke, V Nambi, Vijay Nambi, Vilmundur Gudnason, W Insull Jr., Wendy S Post, Wolfgang Koenig, Wolfgang Rathmann, Xia Li, XZ Zhou, YS Aulchenko, Yu-Ching Cheng   +128 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source