Results 81 to 90 of about 2,278,438 (306)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Cardiovascular Health Trajectories and Prevalent Metabolic Dysfunction‐Associated Steatotic Liver Disease in Midlife: The CARDIA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Metabolic‐dysfunction associated steatotic liver disease (MASLD) is associated with prevalent cardiovascular disease. More favorable cardiovascular health (CVH) profiles are associated with a lower prevalence of MASLD in cross‐sectional ...
Seong W. Park, Hongyan Ning, Mercedes R. Carnethon, Lisa B. VanWagner   +3 more
doaj   +1 more source

Increased systemic inflammation is associated with cardiac and vascular dysfunction over the first 12 weeks of antiretroviral therapy among undernourished, HIV-infected adults in Southern Africa. [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.INTRODUCTION ...
Bala, J, Bestawros, M, Blevins, M, Canipe, A, Chidumayo, T, Filteau, S, Heimburger, DC, Kelly, P, Koethe, JR, Shepherd, BE   +9 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Interpretation of the Annual Report on Cardiovascular Health and Diseases in China 2020

Cardiology Discovery, 2022
The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China
doaj   +1 more source

Bringing some balance to fat bashing

Frontiers in Sustainable Food Systems
Fats and oils are essential to human nutrition, yet often vilified in public discourse and dietary guidelines. We challenge the narrative that all dietary fats are inherently harmful and explore the vital roles fats play in health and food security.
Joanne Slavin, Erik Meijaard, Erik Meijaard, Erik Meijaard, Douglas Sheil, Douglas Sheil   +5 more
doaj   +1 more source

Basal Endogenous Steroid Hormones, Sex Hormone-Binding Globulin, Physical Fitness, and Health Risk Factors in Young Adult Men

Frontiers in Physiology, 2018
Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness.
Sheila S. Gagnon, Sheila S. Gagnon, Bradley C. Nindl, Jani P. Vaara, Jani P. Vaara, Matti Santtila, Keijo Häkkinen, Heikki Kyröläinen, Heikki Kyröläinen   +8 more
doaj   +1 more source

Toward the next generation of research into small area effects on health : a synthesis of multilevel investigations published since July 1998. [PDF]

, 2001
To map out area effects on health research, this study had the following aims: (1) to inventory multilevel investigations of area effects on self rated health, cardiovascular diseases and risk factors, and mortality among adults; (2) to describe and ...
A. Cangelosi, D. C. Plaut, D. Floreano, J. F. Kolen, J. G. Rueckl, R. A Jacobs, R. A. Jacobs, R. Calabretta   +7 more
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Interpretation of the Annual Report on Cardiovascular Health and Diseases in China 2021

Cardiology Discovery, 2023
The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China
doaj   +1 more source