Results 271 to 280 of about 1,136,512 (313)

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

Advanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana, Ryan Sentosa, Caterina Sturtzel, Martin Pfister, René Werkmeister, Anna Schmitt, David Traver, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber   +10 more
wiley   +1 more source

Erratum: Leiter et al. Review of Evolocumab for the Reduction of LDL Cholesterol and Secondary Prevention of Atherosclerotic Cardiovascular Disease. Reviews in Cardiovascular Medicine. 2024; 25: 190. [PDF]

Rev Cardiovasc Med
Leiter LA, Hegele RA, Brown V, Bergeron J, Mackinnon ES, Mancini GBJ.   +5 more
europepmc   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science, EarlyView.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
wiley   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

An Injectable BMP‐2‐Releasing Porous Hydrogel Regulating the Paracrine Effects of ADSCs Promotes Tendon‐to‐Bone Healing in Rotator Cuff Repair

Advanced Science, EarlyView.
This study designs an injectable porous hydrogel (HMs/MBs/ADSCs) integrating hollow microspheres for sustained BMP‐2 release to enhance adipose‐derived stem cells' paracrine effect. It accelerates tendon‐bone healing in rat rotator cuff injuries via spatiotemporal regulation: early AMPK‐mediated mitochondrial protection and late TGF‐β/Smad2/3‐driven ...
Meijuan Yuan, Xiaomei Dai, Yuxia Yang, Shuai Liu, Ziyi Xu, Liang Wang, Junli Shi, Wenkang Liu, Jian Yang, Dianwei Liu, Hang Yao, Wenyong Fei   +11 more
wiley   +1 more source

The Expansion of Genetic Testing in Cardiovascular Medicine: Preparing the Cardiology Community for the Changing Landscape. [PDF]

Curr Cardiol Rep
Reza N, Alford RL, Belmont JW, Marston N.   +3 more
europepmc   +1 more source

Principles of artificial intelligence and its application in cardiovascular medicine. [PDF]

Clin Cardiol
Wieneke H, Voigt I.
europepmc   +1 more source

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Trimetazidine in cardiovascular medicine

International Journal of Cardiology, 2019
Abnormalities of myocardial energy metabolism appear as a common background of the two major cardiac disorders: ischemic heart disease (IHD) and heart failure (HF). Myocardial ischemia has been recently conceived as a multifaceted syndrome that can be precipitated by a number of mechanisms including metabolic abnormalities. HF is a progressive disorder
Marzilli M., Vinereanu D., Lopaschuk G., Chen Y., Dalal J. J., Danchin N., Etriby E., Ferrari R., Gowdak L. H., Lopatin Y., Milicic D., Parkhomenko A., Pinto F., Ponikowski P., Seferovic P., Rosano G. M. C.   +15 more
openaire   +4 more sources

Nanotechnology in cardiovascular medicine [PDF]

Catheterization and Cardiovascular Interventions, 2007
AbstractNanotechnology is a new field of science and technology that has already had significant impact in the development of novel products in industry. In medicine, application of nanotechnology has the potential to develop new imaging agents, pharmaceutical drugs and medical devices with unique physical and chemical properties.
Steven R. Bailey, Devang N. Patel
openaire   +2 more sources

Rapamycin in cardiovascular medicine

Internal Medicine Journal, 2003
Abstract The cellular action of rapamycin (sirolimus), a natural fermentation product produced by Strepto­myces hygroscopicus, is mediated by binding to the FK506 binding protein. By inhibiting a kinase known as the target of rapamycin, it restricts the proliferation of smooth‐muscle cells by blocking cell‐cycle progression at the G1/S transition.The ...
Danièle Muller, Patrick W. Serruys, Peter Ruygrok   +2 more
openaire   +4 more sources