Results 41 to 50 of about 1,109,815 (338)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward

Frontiers in Cardiovascular Medicine, 2022
In 2015, the United Nations set important targets to reduce premature cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD burden and has one of the highest risks of dying from non-communicable diseases ...
Neema W. Minja, Neema W. Minja, Neema W. Minja, Doreen Nakagaayi, Doreen Nakagaayi, Twalib Aliku, Wanzhu Zhang, Isaac Ssinabulya, Isaac Ssinabulya, Juliet Nabaale, Willington Amutuhaire, Sarah R. de Loizaga, Sarah R. de Loizaga, Emma Ndagire, Joselyn Rwebembera, Emmy Okello, Emmy Okello, James Kayima, James Kayima   +18 more
doaj   +1 more source

Leveraging Natural Learning Processing to Uncover Themes in Clinical Notes of Patients Admitted for Heart Failure [PDF]

arXiv, 2022
Heart failure occurs when the heart is not able to pump blood and oxygen to support other organs in the body as it should. Treatments include medications and sometimes hospitalization. Patients with heart failure can have both cardiovascular as well as non-cardiovascular comorbidities.
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

Frontiers in Cardiovascular Medicine, 2020
Background: Heart failure is a pathophysiological state, which is still associated with high morbidity and mortality despite established therapies. Diverse well-known biomarkers fail to assess the variety of individual pathophysiology in the context of ...
Albert Topf, Moritz Mirna, Bernhard Ohnewein, Peter Jirak, Kristen Kopp, Dzeneta Fejzic, Michael Haslinger, Lukas J. Motloch, Uta C. Hoppe, Alexander Berezin, Michael Lichtenauer   +10 more
doaj   +1 more source

The Computational Patient has Diabetes and a COVID [PDF]

arXiv, 2020
Medicine is moving from a curative discipline to a preventative discipline relying on personalised and precise treatment plans. The complex and multi level pathophysiological patterns of most diseases require a systemic medicine approach and are challenging current medical therapies.
arxiv  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Personalized Medicine in Cardiovascular Diseases [PDF]

Korean Circulation Journal, 2012
Personalized medicine is a novel medical model with all decisions and practices being tailored to individual patients in whatever ways possible. In the era of genomics, personalized medicine combines the genetic information for additional benefit in preventive and therapeutic strategies. Personalized medicine may allow the physician to provide a better
Amir Lerman, Andreas J. Flammer, Lilach O. Lerman, Moo-Sik Lee, Moo-Sik Lee   +4 more
openaire   +3 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Transcatheter Mitral Valve Implantation: TMVI Status in 2024

Kardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular Medicine
Today, it is almost 22 years since the first transcatheter aortic valve implant (TAVI) and 11 years since the first transcatheter mitral valve implantation (TMVI) was implanted. TMVI never escalated like TAVI. So far, only one transcatheter mitral valve (
Gry Dahle
doaj   +1 more source