Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source
A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA. [PDF]
BMC MedZhu A, Chakraborty B, Jafar TH.
europepmc +1 more source
Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation
Annals of Neurology, EarlyView.Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko +9 more
wiley +1 more source
Association between periodontitis and cardiovascular mortality, all-cause mortality in patients with congestive heart failure: NHANES 2009-2014. [PDF]
Medicine (Baltimore)Guan F +6 more
europepmc +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
The mediating effect of depression on the association of hearing loss with all-cause and cardiovascular mortality: a prospective cohort study. [PDF]
BMC Public HealthZhang S, Lai H, Liu C.
europepmc +1 more source
Annals of Neurology, EarlyView.Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios +5 more
wiley +1 more source
Joint Association of Depression and Sleep Duration With All-Cause and Cardiovascular Mortality: A Cross-Sectional Study With Inflammation Mediation Analysis. [PDF]
Health Sci RepLi Y, Wu X, Dong J, Jiang X.
europepmc +1 more source
Annals of Neurology, EarlyView.Objective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Dylan N. Wolman +38 more
wiley +1 more source