Results 211 to 220 of about 2,380,266 (312)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Atopic Dermatitis and Markers of Early Cardiovascular Risk in Children and Adolescents.

JAMA Netw Open
Ye M, McCulloch CE, Iribarren C, Langan SM, Abuabara K.   +4 more
europepmc   +1 more source

Age-Dependent Lipid-Cardiovascular Interplay in Patients at High and Very High Cardiovascular Risk. [PDF]

J Clin Med
Baba M, Maris MI, Moroz SM, Gug C, Bucur A, Luca CT, Mozos I.   +6 more
europepmc   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Impact of Y loss in blood on male atherosclerosis and cardiovascular risk

Forsberg L, Bjurling J, Malinovschi A, Jernberg T, Östgren CJ, Engström G, Blomberg A, Gummesson A, Ramesh L, Zaglhool A, Fall T, Hoed Md, Halvardson J.   +12 more
europepmc   +1 more source

Personalized cardiovascular risk management for outdoor activities: a digital health application. [PDF]

Eur Heart J Digit Health
Vecchiato M, Borasio N, Savino S.
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Impact of E-Cigarette Use on Circadian Proteins and Cardiovascular Risk Markers. [PDF]

J Cardiovasc Transl Res
Alzu'bi A, Abu-El-Rub E, Khaswaneh RR, Al-Zubaidi M, Almomani W, Alenaizat A, Ayyash AH, Alragheb A, Alshannag A, Ahmad E, Elaarag M, Al-Zoubi RM.   +11 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

The coming age of coronary atherosclerosis-guided cardiovascular risk prediction and management. [PDF]

Am J Prev Cardiol
Bittencourt MS.
europepmc   +1 more source