Results 31 to 40 of about 875,622 (297)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Development and validation of a prediction model for acute kidney injury following cardiac valve surgery

Frontiers in Medicine
BackgroundAcute kidney injury (AKI) often accompanies cardiac valve surgery, and worsens patient outcome. The aim of our study is to identify preoperative and intraoperative independent risk factors for AKI in patients undergoing cardiac valve surgery ...
Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao   +4 more
doaj   +1 more source

The principles of patients protection from noncardiac complications in cardiac and vascular surgery

Бюллетень сибирской медицины, 2010
The generalized information in area of noncardiac complications prevention are introduced based on results of own researches and literature data (prevention of ischemic stroke, gastroduodenal bleeding and infectious complications in cardiovascular ...
V. B. Loyenko, Ye. A. Sorokina, N. A. Morova, V. E. Smyalovsky, A. V. Gubenko   +4 more
doaj   +1 more source

Managing the Complex Patient with Degenerative Cervical Myelopathy: How to Handle the Aging Spine, the Obese Patient, and Individuals with Medical Comorbidities. [PDF]

, 2018
Degenerative cervical myelopathy (DCM) is the most common cause of nontraumatic spinal cord injury worldwide. Even relatively mild impairment in functional scores can significantly impact daily activities.
Gillick, John, Harrop, James, Rymarczuk, George, Stricsek, Geoffrey   +3 more
core   +1 more source

Health locus of control in patients undergoing coronary artery surgery – changes and associated outcomes: a seven-year cohort study [PDF]

, 2016
Introduction: Health locus of control is a measure of an individual’s beliefs in factors that are thought to determine health experiences. Scores are generated and form a graduated linear scale from external to internal control, with respect to their ...
Lindsay, Grace, Rideout, Andrew, Tolmie, Elizabeth   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Results of surgical treatment of infective endocarditis complicated by acute heart failure

Український журнал клінічної хірургії
Objective. To evaluate the results of surgical treatment of infective endocarditis complicated by acute heart failure. Materials and methods. The clinical data of 72 patients with infective endocarditis complicated by preoperative acute heart failure ...
G. B. Koltunova, A. P. Mazur, O. A. Krikunov   +2 more
doaj   +1 more source

European Guidelines for Obesity Management in Adults [PDF]

, 2015
Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents ...
Busetto, Luca, Fried, Martin, Micic, Dragan, Schindler, Karin, Toplak, Hermann, Tsigos, Constantine, Yumuk, Volkan   +6 more
core   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The Role of Patch Repair in Aortic Arch Reconstruction: Enhancing Outcomes and Preserving Growth Potential in Pediatric Patients

Kardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular Medicine
Objectives: Aortic arch abnormalities are frequently observed in neonates and may be associated with other congenital cardiac anomalies. Various surgical approaches exist for the repair of these abnormalities.
Serkan Seçici, Seyyit Bahaettin Öncü
doaj   +1 more source