Results 201 to 210 of about 192,379 (263)

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Long-Term Outcomes and Imaging Characteristics of Patients with Scimitar Syndrome. [PDF]

J Cardiovasc Dev Dis
Emral HG, Nguyen TVN, Bo I, Semple T, Carvalho JS, Daubeney PEF, Rigby ML, Krupickova S.   +7 more
europepmc   +1 more source

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

Advanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo   +9 more
wiley   +1 more source

Integrated use of natriuretic peptides and DASI for cardiac reserve evaluation in high-risk surgical patients: a narrative review. [PDF]

J Anesth Analg Crit Care
Senussi Testa T, Cuttone G, Damiani F, Ippati G, Zanza C, Misseri G, La Via L.   +6 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Surgical myectomy for hypertrophic cardiomyopathy: procedural volume and outcomes. [PDF]

Eur Heart J
Heeringa TJP, Hegeman RMJJ, Koop Y, El Mathari S, Hoogewerf M, Roefs MM, Smits KC, Laenens D, De Zan G, Cramer MJ, Guglielmo M, van der Harst P, Vaartjes I, Mokhles MM, Klein P, van der Kaaij NP.   +15 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Characteristics of patients qualified for aortic valve replacement combined with coronary artery bypass grafting surgery in the era of transcatheter aortic valve implantation dominance study (CAPTOR study). [PDF]

J Thorac Dis
Reszczyński M, Litwinowicz R, Brzeziński M, Perek B, Kowalewski M, Widenka K, Bartuś K, Burysz M.   +7 more
europepmc   +1 more source

Early and long-term results in patients undergoing combined coronary and lower extremity revascularization: a retrospective analysis. [PDF]

J Cardiothorac Surg
Yilmaz M, Kehlibar T, Arslan IY, Gunay R, Yilmaz H, Kurc E, Tuygun AK, Ketenci B, Yapici F, Ozler A.   +9 more
europepmc   +1 more source

Income and Geographic Disparities in in-Hospital Mortality Following Cardiovascular Procedures: Evidence From the National Inpatient Sample, 2016-2022. [PDF]

Health Serv Res
Bergman A, Nathan A.
europepmc   +1 more source