Results 101 to 110 of about 311,401 (301)

Building on the Promise: State Initiatives to Expand Access to Early Head Start for Young Children and Their Families [PDF]

, 2008
Discusses twenty states' approaches to expanding and enhancing Early Head Start services, opportunities and challenges for state initiatives, and recommendations for building on existing services for at-risk children.
Elizabeth DiLauro, Rachel Schumacher
core  

Framework for better living with HIV in England [PDF]

, 2009
1 Introduction and overview 1.1 The goal, purpose and scope of the framework This framework is the first of its kind in the UK. It describes the shared aspirations of a group of agencies for the lives of people diagnosed with HIV in England. The
Azad, Yusef, Carter, Michael, Crafer, Elizabeth, Cregan, Sinead, Keogh, Peter, Morley, Chris, Nkwenti, Priscilla, Nutland, Will, Pebody, Roger, Reynolds, Rhon, Summerside, Jack, Weatherburn, Peter   +11 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Who provides care in the last year of life? A description of care networks of community-dwelling older adults in the Netherlands

BMC Palliative Care, 2019
Background Home-based care networks differ in size and composition, but little is known about the characteristics of care networks for those nearing the end of their lives.
Femmy M. Bijnsdorp, H. Roeline W. Pasman, Anneke L. Francke, Natalie Evans, Carel F. W. Peeters, Marjolein I. Broese van Groenou   +5 more
doaj   +1 more source

Patient safety culture in a large teaching hospital in Riyadh: baseline assessment, comparative analysis and opportunities for improvement [PDF]

, 2011
Gas chromatography–mass spectrometry (GC-MS) is a widely used analytical technique in metabolomics. GC provides the highest resolution of any standard chromatographic separation method, and with modern instrumentation, retention times are very consistent
Ayman Abdo, Diana Jamal, Fadi El-Jardali, Farheen Sheikh, Nereo A Garcia   +4 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reported impact and protective factors of the care partner role during persistent critical illness: a content analysis

BMC Nursing
Background Patients with persistent critical illness experience prolonged multi-system morbidity, functional impairments, and chronic conditions. As a result, these patients have prolonged intensive care unit admissions.
Laura Istanboulian, Anthony J. Gilding, Lorrie Hamilton, Tasneem Master, Sarah Bingler, Karen Soldatic, Kelly M. Smith   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Using co‐design to adapt the care partner hospital assessment tool for dementia

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Care partners play a critical role in supporting hospitalized individuals with dementia. The Care Partner Hospital Assessment Tool (CHAT) is a standardized tool for identifying and training care partners, but has not been adapted for ...
Beth Fields, Benazir Meera, Kathryn Istvanek, Te‐Lien Ku, Hanna J. Barton, Chloe Muntefering, Nicole E. Werner   +6 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source