Results 121 to 130 of about 311,401 (301)

Health Care Providers’ Well-being Indicators are Associated With Their Intention to Leave Their Positions: A Cross-Sectional Study From Saskatchewan, Canada

Inquiry: The Journal of Health Care Organization, Provision, and Financing
This study aimed to measure the intention to leave and well-being indicators (ie, job satisfaction, burnout, moral distress, risk of depression, and resilience) of health care providers (HCPs) in Saskatchewan, Canada and to explore the association ...
Tasbeen Akhtar Sheekha MSc, Noelle Rohatinsky PhD, Jacob Albin Korem Alhassan PhD, Dennis Kendel MD, Carmen Levandoski BSN, Jeff Dmytrowich RT, Tenille Lafontaine, Matthew Cardinal, Juan Nicolás Peña-Sánchez PhD   +8 more
doaj   +1 more source

The Dementia Care Partner Hub: A novel resource to support people living with dementia, care partners, and care teams

Alzheimer's & Dementia
AbstractCare partners of people living with dementia (PLWD) need information and access to many services and programs to support their person and maintain their own wellbeing. We conducted focus groups (n = 5) and interviews (n = 24) with care partners of PLWD and interviews with leaders of organizations serving PLWD in the Portland, Oregon region in ...
Gelmon, Sherril B, Dawson, Walter D, Reed, Jenn Hollandsworth   +2 more
openaire   +1 more source

One Out of Every Five: Teen Mothers and Subsequent Childbearing [PDF]

, 1998
The birth of a child to a teenager puts the young family at risk for negative social and health consequences; the birth of additional children can further impede the family's financial, academic, and social success. Though there is a national interest in
Florencia M. Greer, Jodie Levin-Epstein
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Intimate partner violence and postpartum depression: a moderated mediation model of fear of birth and antenatal care

BMC Public Health
Background Intimate partner violence is a serious social problem affecting maternal mental health and has been confirmed to be associated with postpartum depression.
Mengmei Yuan, Zining Zhu, Tieying Zeng, Ke Zhang   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Randomized clinical trial of ICECaP (Individualized Coordination and Empowerment for Care Partners of Persons with Dementia): Primary mental health and burden outcomes.

PLoS ONE
We examine the efficacy of the Individualized Coordination and Empowerment for Care Partners of Persons with Dementia (ICECaP), an intervention that involves one-on-one individualized support from a dementia care coordinator for a dementia care partner ...
Virginia T Gallagher, Anna Arp, Ryan Thompson, M Agustina Rossetti, James Patrie, Shannon E Reilly, Carol Manning   +6 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source