Results 91 to 100 of about 3,999,178 (276)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Book review: Beyond 18 - Leaving child care institutions: a study of aftercare practices in five states of India. UNICEF: India Country Office

open access: yesScottish Journal of Residential Child Care, 2020
This is a review of an overview report of a study conducted by Udayan Care in India with support from the United Nations Children's Fund (UNICEF), Tata Trusts and the five State Governments of Delhi, Gujarat, Karnataka, Maharashtra and Rajasthan.
Kenny McGhee
doaj   +1 more source

Who are children in care and care leavers

open access: yes, 2020
The chapter focuses on the characteristics and experiences of minors accepted in public structures and care leavers. Most of the children housed in the facilities come from problematic families, punctuated by recurrent crises. Precisely for this reason in many European countries the awareness has matured that the minors accepted in the social-welfare ...
ELISABETTA DI GIOVANNI   +1 more
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Turning Point Processes to Higher Education among Care Leavers

open access: yesSocial Work and Society, 2014
Children who grew up in care institutions encounter many difficulties in the years after leaving care, including challenges related to their low education achievements while they were still in care. Higher education is therefore hard and sometimes almost
Tehila Refaeli, Benjamin Strahl
doaj   +2 more sources

Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol - Exploring associations in a high-risk sample of young adult residential care leavers. [PDF]

open access: yesBrain Behav Immun Health, 2022
Bürgin D   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Care-Leavers’ Views on Their Preparation for Leaving Residential Care in South Africa

open access: yesYouth
The process of youth leaving residential care, for those who grew up in care, remains a global challenge. In South Africa, leaving care is complicated by the almost complete absence of aftercare support services, and a general lack of preparation for ...
Nellie Sandy Seale, Adrian D. van Breda
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

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