Results 81 to 90 of about 3,999,164 (276)

The Intersection of Leaving Care and Homelessness: A Literature Overview in a Nordic Welfare State Context

Nordisk Välfärdsforskning
Care leavers are significantly overrepresented among young homeless people, a phenomenon that can be found internationally as well as within the Nordic countries.
Alberte Alsø Dokkedal, Veera Niemi, Freydís Freysteinsdóttir, Anne-Kirstine Mølholt, Mattias Bengtsson, Veronika Paulsen, Eva Dögg Sigurðardóttir   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Trajectories of care leavers according to indicators of psychosocial adjustment: A cohort analysis

Child Protection and Practice
Background: The study of the trajectories of care leavers regarding their involvement with a series of public services and institutions contributes to identify some indicators of psychosocial adjustment and therefor make proposals of improvement in their
Carme Montserrat, Joan Llosada-Gistau
doaj   +1 more source

Exploring outcomes for children who have experienced out-of-home care in Western Australia.

International Journal of Population Data Science, 2018
Introduction Children who have been in out-of-home care have faced significant issues during their lives, and they are considered one of the most vulnerable groups in society.
Fernando Lima
doaj   +1 more source

Overcoming the odds: demonstrating aftercare model of providing targeted support to care experienced youth

Scottish Journal of Residential Child Care, 2023
Aftercare is a vital continuum of care process, crucial for care experienced youths to fully realise their true potential and thereby become resilient members of society.
Kiran Modi, Gurneet Kaur Kalra
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Listening to care leavers: a case study involving 435 care leavers and 100 child protection key stakeholders in 5 States of India

Scottish Journal of Residential Child Care
A research study by Udayan Care (Beyond 18: Leaving Child Care Institutions-Supporting Youth Leaving Care, A Study of Aftercare Practices, 2019), in India, reveals that even though, as per the Juvenile laws of India, 'care-experienced' youth (care ...
Kiran Modi, Gurneet Kaur Kalra
doaj   +1 more source

What Makes a Difference? Turning Points for Young People in the Process of Leaving Placements in Public Care.

Social Work and Society, 2014
The purpose of this study is to examine young care leavers’ narrative accounts expressed as turning points connected to their experiences of being in care and leaving care. Telephone interviews were conducted with 65 young people, between 18 and 26 years
Ingrid Höjer, Yvonne Sjöblom
doaj   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source