Results 81 to 90 of about 4,229,194 (277)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Candles and care

open access: yesScottish Journal of Residential Child Care, 2013
A group of Scottish care leavers visited Denmark to undertake a comparative piece of research looking at the similarities and differences between care and leaving care provision in the respective countries.
Julieann Arthur   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Trajectories of care leavers according to indicators of psychosocial adjustment: A cohort analysis

open access: yesChild Protection and Practice
Background: The study of the trajectories of care leavers regarding their involvement with a series of public services and institutions contributes to identify some indicators of psychosocial adjustment and therefor make proposals of improvement in their
Carme Montserrat, Joan Llosada-Gistau
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Listening to care leavers: a case study involving 435 care leavers and 100 child protection key stakeholders in 5 States of India

open access: yesScottish Journal of Residential Child Care
A research study by Udayan Care (Beyond 18: Leaving Child Care Institutions-Supporting Youth Leaving Care, A Study of Aftercare Practices, 2019), in India, reveals that even though, as per the Juvenile laws of India, 'care-experienced' youth (care ...
Kiran Modi, Gurneet Kaur Kalra
doaj   +1 more source

Exploring outcomes for children who have experienced out-of-home care in Western Australia.

open access: yesInternational Journal of Population Data Science, 2018
Introduction Children who have been in out-of-home care have faced significant issues during their lives, and they are considered one of the most vulnerable groups in society.
Fernando Lima
doaj   +1 more source

Understanding Care Leavers in Russia: Young People's Experiences of Institutionalisation.

open access: yes, 2014
Care leavers in Russia represent one of the most disadvantaged groups in society. However, they have rarely been the focus of welfare policy debate and they receive little or no support in their independent living.
Hackett, S., Stepanova, E.
core   +1 more source

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