Results 91 to 100 of about 3,999,164 (276)
"Don't stand up on unlevel ground": Care leavers' experiences of out-of-home care
Background: Children and young people in contact with child protection services often experience poorer life outcomes compared to their peers. Limited research exists on the reasons behind this disparity from the perspective of those with direct lived ...
Grieg, Hannah +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Internet-Based Prevention Program of Victimization for Youth in Care and Care Leavers (EMPOWER YOUTH): Protocol for a Randomized Controlled Trial. [PDF]
JMIR Res Protoc, 2022 Wagner B, Reuter L, van Noort BM.
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Turning Point Processes to Higher Education among Care Leavers
Social Work and Society, 2014 Children who grew up in care institutions encounter many difficulties in the years after leaving care, including challenges related to their low education achievements while they were still in care. Higher education is therefore hard and sometimes almost
Tehila Refaeli, Benjamin Strahl
doaj +2 more sources
Scottish Journal of Residential Child Care, 2020 This is a review of an overview report of a study conducted by Udayan Care in India with support from the United Nations Children's Fund (UNICEF), Tata Trusts and the five State Governments of Delhi, Gujarat, Karnataka, Maharashtra and Rajasthan.
Kenny McGhee
doaj +1 more source
Crossing Countries and Crossing Ages: The Difficult Transition to Adulthood of Unaccompanied Migrant Care Leavers. [PDF]
Int J Environ Res Public Health, 2021 Gullo F +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source