Results 91 to 100 of about 2,366 (253)

Who are children in care and care leavers

open access: yes, 2020
The chapter focuses on the characteristics and experiences of minors accepted in public structures and care leavers. Most of the children housed in the facilities come from problematic families, punctuated by recurrent crises. Precisely for this reason in many European countries the awareness has matured that the minors accepted in the social-welfare ...
ELISABETTA DI GIOVANNI   +1 more
openaire   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Factors Affecting Care Leavers in Their Transition to Adulthood: Differences Between National and Migrant Youth in Andalusia (Spain)

open access: yesRevista de Estudios Sociales
Both care leavers and non-care leavers go through a transition to adulthood marked by challenges in various aspects of their lives. However, there are significant differences between young nationals and foreign youths who have exited the protection ...
Verónica Sevillano-Monje   +3 more
doaj   +1 more source

Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol - Exploring associations in a high-risk sample of young adult residential care leavers. [PDF]

open access: yesBrain Behav Immun Health, 2022
Bürgin D   +9 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Children and young people in care until age 26: a must for improved outcomes

open access: yesScottish Journal of Residential Child Care, 2013
Care Leavers have the worst outcomes in our society across most social well-being indicators. This is even more shocking as they are as physically and mentally capable as any other Scot.
Duncan Dunlop
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Care Leavers' Experiences of Transition and Turning Points: Findings from a Biographical Narrative Study

open access: yesSocial Work and Society, 2014
This paper reports on the findings of a PhD research project that set out to explore how young people leaving out of home care experienced and made sense of their transition to adulthood.
John Pinkerton, Carmel Rooney
doaj   +2 more sources

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