Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Crossing Countries and Crossing Ages: The Difficult Transition to Adulthood of Unaccompanied Migrant Care Leavers. [PDF]
Int J Environ Res Public Health, 2021 Gullo F +3 more
europepmc +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Social Work and Society, 2014 The purpose of this study is to examine young care leavers’ narrative accounts expressed as turning points connected to their experiences of being in care and leaving care. Telephone interviews were conducted with 65 young people, between 18 and 26 years
Ingrid Höjer, Yvonne Sjöblom
doaj +2 more sources
Internet-Based Prevention Program of Victimization for Youth in Care and Care Leavers (EMPOWER YOUTH): Protocol for a Randomized Controlled Trial. [PDF]
JMIR Res Protoc, 2022 Wagner B, Reuter L, van Noort BM.
europepmc +1 more source
‘Who am I?’ How female care-leavers construct and make sense of their identity. [PDF]
, 2019 Identity formation may be more complex for those who have been in foster care in the face of childhood abuse, difficult relationships, unstable environments and multiple care contexts but this does not imply there is anything pathological about it. Given
Hassett, A., Colbridge, A.
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Corporate parenting in a pandemic: Considering the delivery and receipt of support to care leavers in Wales during Covid-19. [PDF]
Child Youth Serv Rev, 2021 Roberts L +6 more
europepmc +1 more source
"Don't stand up on unlevel ground": Care leavers' experiences of out-of-home care
Background: Children and young people in contact with child protection services often experience poorer life outcomes compared to their peers. Limited research exists on the reasons behind this disparity from the perspective of those with direct lived ...
Grieg, Hannah +3 more
core +1 more source