Results 71 to 80 of about 4,149,654 (191)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Life course health and mental health of care leavers after age 30: a scoping review

Scottish Journal of Residential Child Care
Foster care outcome research provides critical insights into the impacts and efficacy of child welfare interventions as well as the developmental needs of those who experience placement.
Amanda Keller, Yunung Lee, Nikki Tummon, Michael Mackenzie   +3 more
doaj   +1 more source

The Care Leavers’ Annual Lecture 2016

Scottish Journal of Residential Child Care, 2017
A care experienced person is invited to host the Who Cares? Scotland Care Leavers Annual Lecture, and this is the transcript of the lecture from 2016. Jimmy Paul, an alumni member of Who Cares?
Jimmy Paul
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Intersection of Leaving Care and Homelessness: A Literature Overview in a Nordic Welfare State Context

Nordisk Välfärdsforskning
Care leavers are significantly overrepresented among young homeless people, a phenomenon that can be found internationally as well as within the Nordic countries.
Alberte Alsø Dokkedal, Veera Niemi, Freydís Freysteinsdóttir, Anne-Kirstine Mølholt, Mattias Bengtsson, Veronika Paulsen, Eva Dögg Sigurðardóttir   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The role of social support in the association between adolescent emotional and behavioral problems and quality of life in young adulthood in youth residential care leavers

BMC Public Health
Background Adults with a history of residential out-of-home care (care leavers) often experience emotional and behavioral problems, which can negatively impact quality of life (QoL) into adulthood.
Milou Leiting, Katharina Beck, Süheyla Seker, David Bürgin, Delfine d’Huart, Jörg M. Fegert, Nils Jenkel, Cyril Boonmann, Klaus Schmeck, Marc Schmid   +9 more
doaj   +1 more source

Candles and care

Scottish Journal of Residential Child Care, 2013
A group of Scottish care leavers visited Denmark to undertake a comparative piece of research looking at the similarities and differences between care and leaving care provision in the respective countries.
Julieann Arthur, Alexander Horne, Murray McKinnon, Jeremy Millar   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Understanding Care Leavers in Russia: Young People's Experiences of Institutionalisation.

, 2014
Care leavers in Russia represent one of the most disadvantaged groups in society. However, they have rarely been the focus of welfare policy debate and they receive little or no support in their independent living.
Hackett, S., Stepanova, E.
core   +1 more source