Results 51 to 60 of about 2,319 (253)
The Care Leavers’ Annual Lecture 2016
Scottish Journal of Residential Child Care, 2017 A care experienced person is invited to host the Who Cares? Scotland Care Leavers Annual Lecture, and this is the transcript of the lecture from 2016. Jimmy Paul, an alumni member of Who Cares?
Jimmy Paul
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Scottish Journal of Residential Child Care, 2013 A group of Scottish care leavers visited Denmark to undertake a comparative piece of research looking at the similarities and differences between care and leaving care provision in the respective countries.
Julieann Arthur +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Life course health and mental health of care leavers after age 30: a scoping review
Scottish Journal of Residential Child CareFoster care outcome research provides critical insights into the impacts and efficacy of child welfare interventions as well as the developmental needs of those who experience placement.
Amanda Keller +3 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Trajectories of care leavers according to indicators of psychosocial adjustment: A cohort analysis
Child Protection and PracticeBackground: The study of the trajectories of care leavers regarding their involvement with a series of public services and institutions contributes to identify some indicators of psychosocial adjustment and therefor make proposals of improvement in their
Carme Montserrat, Joan Llosada-Gistau
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nordisk VälfärdsforskningCare leavers are significantly overrepresented among young homeless people, a phenomenon that can be found internationally as well as within the Nordic countries.
Alberte Alsø Dokkedal +6 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source